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Valinomycin is an antibiotic which acts as a potassium (K+) ionophore. Induces K+ conductivity in cell membranes. Also active in vitro against Mycobacterium Tuberculosis, and as an apoptosis inducer.
Valinomycin is used diagnostically in ion selective electrodes because of its preferential ability to conduct K+ across the electrode’s membrane.
In valinomycin induced stimulation of mitochondrial energy dependent reversible swelling, supported by succinate oxidation, cytochrome c (cyto-c) and sulfite oxidase (Sox) [both present in the mitochondrial intermembrane space (MIS)] are released outside.1 Valinomycin induced energy-dependent mitochondrial swelling, cytochrome c release, cytosolic NADH/cytochrome c oxidation and apoptosis. DD Lofrumento, G La Piana, et al, October 1, 2011; 16(10): 1004-13.
Valinomycin also inhibited hyphal growth in other dimorphic fungi, Candida tropicalis and Aureobasidium pullulans.2 Valinomycin affects the morphology of Candida albicans. H Watanabe, M Azuma, et al, December 1, 2005; 58(12): 753-8.
|CAS #||CAS [2001-95-8]|
|Merck Index||Merck Index: 13.9978.2001|
|Molecular Weight||M.W. 1111.34|
|Purity||Purity: >90% by HPLC & >95% by TLC|
|Solubility||Soluble in Methanol, Ethanol, Hexane & DMSO. Water insoluble|
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