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Valinomycin | CAS 2001-95-8 | Potassium ionophore

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Valinomycin

CAS: 2001-95-8 Formula: C54H90N6O18 MW: 1111.34 Appearance: White Solid Purity: 90% by HPLC & 95% by TLC
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V-1013 100 mg
$134.42
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Valinomycin is an antibiotic which acts as a potassium (K+) ionophore. Induces K+ conductivity in cell membranes. Also active in vitro against Mycobacterium Tuberculosis, and as an apoptosis inducer.

Valinomycin is used diagnostically in ion selective electrodes because of its preferential ability to conduct K+ across the electrodes membrane. Valinomycin induced stimulation of mitochondrial energy dependent reversible swelling, supported by succinate oxidation, cytochrome c (cyto-c) and sulfite oxidase (Sox) are released outside. Valinomycin induced energy-dependent mitochondrial swelling, cytochrome c release, cytosolic NADH/cytochrome c oxidation and apoptosis. Valinomycin also inhibited hyphal growth in other dimorphic fungi, Candida tropicalis and Aureobasidium pullulan. Valinomycin affects the morphology of Candida albicans.

Additional Information

Product # V-1013
CAS # 2001-95-8
Chemical Name (2S,8R,11S,14S,17R,20R,23S,26S,29R,32R,35S)-2,14,26-TRIMETHYL-5,8,11,17,20,23,29,32,35-NONA(PROPAN-2-YL)-3,9,15,21,27,33-HEXAOXA-6,12,18,24,30,36-HEXAZACYCLOHEXATRIACONTANE-1,4,7,10,13,16,19,22,25,28,31,34-DODECONE
Formula C54H90N6O18
MW 1111.34
Appearance White Solid
Purity 90% by HPLC & 95% by TLC
Solubility Soluble in Methanol, Ethanol, Hexane & DMSO. Water insoluble
Melting Point 184-190 °C
Boiling Point 1321.60 °C at 760 mmHg
Storage Temp -20°C
Therapeutic Area Pulmonary Disorders
Use Valinomycin is potent agent against severe acute respiratory-syndrome coronavirus (SARS-CoV) in infected Vero E6 cells

Additional Information

Merck Index Merck Index: 13.9978.2001
MDL Number MFCD00005114
ChemACX X1008618-5
InChI InChI=1S/C54H90N6O18/c1-22(2)34-49(67)73-31(19)43(61)55-38(26(9)10)53(71)77-41(29(15)16)47(65)59-36(24(5)6)51(69)75-33(21)45(63)57-39(27(11)12)54(72)78-42(30(17)18)48(66)60-35(23(3)4)50(68)74-32(20)44(62)56-37(25(7)8)52(70)76-40(28(13)14)46(64)58-34/h22-42H,1-21H3,(H,55,61)(H,56,62)(H,57,63)(H,58,64)(H,59,65)(H,60,66)/t31-,32-,33-,34+,35+,36+,37-,38-,39-,40+,41+,42+/m0/s1
SMILES C[C@H]1C(=O)N[C@H](C(=O)O[C@@H](C(=O)N[C@@H](C(=O)O[C@H](C(=O)N[C@H](C(=O)O[C@@H](C(=O)N[C@@H](C(=O)O[C@H](C(=O)N[C@H](C(=O)O[C@@H](C(=O)N[C@@H](C(=O)O1)C(C)C)C(C)C)C(C)C)C)C(C)C)C(C)C)C(C)C)C)C(C)C)C(C)C)C(C)C

Additional Information

RTECS YV9468000
UN #'S UN 3462
PACKING GROUP I
Handling Warning.Toxic. Eye irritant. Wear gloves/mask when handling product. Avoid contact by all means of exposure.

Additional Information

msds 1 V-1013, SDS.pdf
Certificate of Analysis 1 V-1013, G1332.pdf
Certificate of Analysis 2 V-1013, G1310.pdf
Certificate of Analysis 3 V-1013, F1101.pdf

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Valinomycin

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