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Embryonic stem cells are capable of self-renewing and differentiating. Stem cell homeostasis is maintained through epigenetic mechanisms that are highly dynamic in regulating the chromatin structure as well as specific gene transcription programs. Epigenetics has involved changes in gene expression, which are heritable through modifications not affecting the DNA sequence. Epigenetic mechanism includes: DNA methylation, histone modifications, and ATP-dependent chromatin remodeling.
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FREE REVIEW ARTICLES
- Epigenetics and its Implications for Plant Biology 2. The ‘Epigenetic Epiphany’: Epigenetics, Evolution and Beyond, R. T. GRANT-DOWNTON and H. G. DICKINSON. Epigenetics and its Implications for Plant Biology 2. The ‘Epigenetic Epiphany’: Epigenetics, Evolution and Beyond. Ann. Bot, 2006; 97: 11 - 27.
- Epigenetics in cancer: Targeting chromatin modifications, Leigh Ellis, Peter W. Atadja, and et al. Epigenetics in cancer: Targeting chromatin modifications. Mol. Cancer Ther, 2009; 8: 1409 - 1420.
- Epigenetics: A New Bridge between Nutrition and Health, Sang-Woon Choi and Simonetta Friso. Epigenetics: A New Bridge between Nutrition and Health.Adv Nutr, 2010; 1: 8 - 16.