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JAK / STAT Signaling

The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors.

Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.

Click here to View the Jak-STAT Signaling Pathway

 

 

  1. CP-690550

    CP-690550

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    C-2271 477600-75-2 5 mg
    $273.48
    25 mg
    $820.44
  2. CRT Inhibitor, iCRT5

    CRT Inhibitor, iCRT5

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    C-2273 18623-44-4 5 mg
    $85.00
    25 mg
    $320.00
  3. Dorsomorphin Inhibit Myostatin / GDF8 Signaling, inhibits Bmp-Smad pathway

    Dorsomorphin, DM, AMPK Inhibitor

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    D-1310 866405-64-3 5 mg
    $121.78
  4. Janex-1

    Janex-1

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    W-2482 202475-60-3 5 mg
    $129.00
    25 mg
    $407.64
  5. Lestaurtinib

    Lestaurtinib

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    L-2374 111358-88-4 500 ug
    $87.72
    1 mg
    $149.64
    5 mg
    $536.64
  6. MS-1020

    MS-1020

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    M-2357 1 mg
    $101.14
  7. PathwayReady JAK/STAT Signaling Inhibitor Panel

    PathwayReady JAK/STAT Signaling Inhibitor Panel

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    P-2382 8 inhibitors
    $851.40
  8. PP2 | CAS#172889-27-9 |  Selective Src tyrosine kinase inhibitor |Src cellular signaling, PP2 is a substance used in cancer research as a selective inhibitor for Src-family kinasesPP2 is a substance used in cancer research as a selective inhibitor for Src

    PP2

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    P-1103 172889-27-9 1 mg
    $84.62
    5 mg
    $330.24
  9. TAK 165

    TAK 165

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    T-2450 366017-09-6 5 mg
    $87.72
    25 mg
    $304.44
  10. Tyrphostin, AG 490

    Tyrphostin, AG 490

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    A-1164 133550-30-8 5 mg
    $47.88
    10 mg
    $80.50
    25 mg
    $201.29
    50 mg
    $319.92
  11. WP1066

    WP1066

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    W-2483 857064-38-1 5 mg
    $98.04
    25 mg
    $392.16