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PI3K / AKT / mTOR Signaling

The PI3K/AKT/mTOR pathway is an intracellular signalling pathway important in apoptosis and hence cancer e.g. breast cancer and non-small-cell lung cancer. mTOR signaling pathway. PI3K activation activates AKT which activates mTOR. ('PDK1' in the diagram is Phosphoinositide-dependent kinase-1.) 

In many cancers this pathway is overactive reducing apoptosis and allowing proliferation. Thus some experimental cancer drugs aim to inhibit the signalling sequence at some point. The PI3K pathway may be overactive because PTEN is faulty or deficient.  

 

 Click Here to View the mTOR Signaling Pathway

 

 

  1. (±)-cis,trans-Abscisic Acid | CAS [14375-45-2] | Plant Growth Hormone. Offered in catalog & bulk by A.G. Scientific, Inc.

    (±)-cis,trans-Abscisic Acid

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    A-1094 14375-45-2 1 g
    $243.30
    5 g
    $757.61
  2. BEZ235

    BEZ235

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    B-2199 915019-65-7 5 mg
    $133.39
    25 mg
    $314.79
  3. DiscoveryPak PI 3-Kinase Inhibitor Set

    DiscoveryPak PI 3-Kinase Inhibitor Set

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    D-2292 5 inhibitors
    $464.18
  4. GDC-0941

    GDC-0941

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    G-2335 957054-30-7 1 mg
    $170.61
    5 mg
    $584.21
  5. Ins(3,4,5,6)P4

    Ins(3,4,5,6)P4

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    P-1111 100 ug
    $184.87
    500 ug
    $470.58
  6. KU-55933

    KU-55933

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    A-2189 587871-26-9 5 mg
    $176.07
  7. L-myoIns(1,4,5)P3.6K

    L-myoIns(1,4,5)P3.6K

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    I-1038 129828-71-3 1 mg
    $117.65
  8. LY294002 EZSolution™

    LY294002 EZSolution™

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    E-2312 154447-36-6 5 mg
    $85.37
  9. Neomycin.Sulfate | CAS 1405-10-3 | Antibiotic inhibits translation. An aminoglycoside antibiotic that inhibits translation by binding to the small subunit of prokaryotic ribosomes.

    Neomycin.Sulfate

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    N-1053 1405-10-3 25 g
    $18.14
    100 g
    $44.81
  10. PathwayReady PI3-K/Akt/mTOR Signaling Inhibitor Panel

    PathwayReady PI3-K/Akt/mTOR Signaling Inhibitor Panel

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    P-2384 11 inhibitors
    $997.73
  11. Phosphatidylinositol 3-Kinase SH3 Domain Binding Peptide

    Phosphatidylinositol 3-Kinase SH3 Domain Binding Peptide

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    P-1143 1 mg
    $93.91
  12. PI diC8

    PI diC8

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    P-1555 500 ug
    $229.42
    1 mg
    $432.17
  13. PI(3)diC16

    PI(3)diC16

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    P-1557 500 ug
    $229.42
    1 mg
    $432.17
  14. PI(4)P, di C8

    PI(4)P, di C8

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    P-1135 100 ug
    $96.04
    500 ug
    $288.11
  15. PI(4,5)P2, di C16

    PI(4,5)P2, di C16

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    P-1117 100 ug
    $64.03
    500 ug
    $224.09
  16. PI(4,5)P2,di C8

    PI(4,5)P2,di C8

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    P-1115 100 ug
    $74.70
    500 ug
    $224.09
  17. PI(5), di C16

    PI(5), di C16

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    P-1141 100 ug
    $64.03
    500 ug
    $224.09
  18. PI-103

    PI-103

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    P-2394 371935-74-9 1 mg
    $96.04
    5 mg
    $346.80
  19. PI3-K gamma Inhibitor, AS-605240

    PI3-K gamma Inhibitor, AS-605240

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    P-2395 648450-29-7 1 mg
    $69.36
    5 mg
    $261.44
  20. TGX-221

    TGX-221

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    T-2460 663619-89-4 1 mg
    $90.70
    5 mg
    $346.80
  21. Wortmannin

    Wortmannin

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    W-1022 19545-26-7 1 mg
    $53.35
    5 mg
    $160.06
    25 mg
    $624.25