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TGFBETA / SMAD Signaling

The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members.

TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.

 

Click Here to View the TGF-Beta Signaling Pathway

 

 

  1. A83-01

    A83-01

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    A-1764 909910-43-6 1 mg
    $102.17
  2. S-2122, SB-431542, An inhibitor of the TGF-β 1 receptor ALK5, CAS# 301836-41-9, A.G. Scientific, Figure displaying SB-431542 inducing morphological defects in embryos

    SB-431542

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    S-2122 301836-41-9 1 mg
    $98.04