Cell Damage Oxidative Stress

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Cell Damage Oxidative Stress

Cell Damage Oxidative Stress

Oxidative stress represents an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage. Disturbances in the normal redox state of cells can cause toxic effects through the production of peroxides and free radicals that damage all components of the cell, including proteins, lipids, and DNA. Further, some reactive oxidative species act as cellular messengers in redox signaling. Thus, oxidative stress can cause disruptions in normal mechanisms of cellular signaling.

In humans, oxidative stress is thought to be involved in the development of many diseases or may exacerbate their symptoms. These include cancer, Parkinson's disease, Alzheimer's disease, atherosclerosis, heart failure, myocardial infarction, Schizophrenia; Bipolar disorder, fragile X syndrome, Sickle Cell Disease,and chronic fatigue syndrome. However, reactive oxygen species can be beneficial, as they are used by the immune system as a way to attack and kill pathogens. Short-term oxidative stress may also be important in prevention of aging by induction of a process named mitohormesis.

FREE REVIEW ARTICLES

Oxidative stress and condition-dependent sexual signals: more than just seeing red, Michael Garratt and Robert C. Brooks. Oxidative stress and condition-dependent sexual signals: more than just seeing red. Proc R Soc B, 2012; 279: 3121 - 3130.

Oxidative stress and redox signaling mechanisms of inflammatory bowel disease: updated experimental and clinical evidence, Hong Zhu and Y Robert Li. Oxidative stress and redox signaling mechanisms of inflammatory bowel disease: updated experimental and clinical evidence. Exp Biol Med, 2012; 237: 474 - 480.

Oxidative Stress-Mediated Regulation of Proteasome Complexes, Charity T. Aiken, Robyn M. Kaake, et al. Oxidative Stress-Mediated Regulation of Proteasome Complexes. Mol. Cell. Proteomics, 2011; 10: R110.006924.

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Product Number	A-1010
CAS #	CAS [1614-12-6]
Chemical Formula	C₆H₆N₄
Molecular Weight	M.W. 134.1
Purity	Purity: > 98%
Solubility	Readily Soluble in Water and Dilute Aqueous Base.
Storage Temp	Room Temp

1-Aminobenzotriazole Product Number: A-1010
Price	Price	Qty	Add to Cart
1x100 mg	$119.00

Product Number	P-2415
Alternative Name	Proteina/g, protein ag, protein a/g, proteinag, protein-ag, protein-a/g, proteinag, Protein A/G, rProtein A/G, r-protein A/G, recombinant protein A/G, IgG purification, antibody purification, Protein A, Protein G, Protein A&G
Appearance	Lyophilized
Molecular Weight	59.7 kDa
Purity	≥98%
Storage Temp	-20°C

Protein A/G, Recombinant Product Number: P-2415
Price	Price	Qty	Add to Cart
1x1 mg	$85.00
1x5 mg	$235.00
1x25 mg	$895.00
1x100 mg	$2,550.00
1x1 g	$12,500.00

Product Number	A-1476
CAS #	CAS[10537-47-0]
Chemical Name	(3,5-Di-t-butyl-4-hydroxybenzylidene)-malononitrile α-Cyano-(3,5-di-tert.butyl-4-hydroxy)cinnamonitrile
Chemical Formula	C₁₈H₂₂N₂O
Alternative Name	Tyrphostin 9, Tyrphostin RG 50872
Appearance	Yellow solid.
Molecular Weight	M.W.282.4
Purity	Purity:≥98%
Solubility	Soluble in DMSO or 100% ethanol. Insoluble in water.
Storage Temp	Room Temp

AG 9 Product Number: A-1476
Price	Price	Qty	Add to Cart
1x50 mg	$72.00

Product Number	O-1078
Alternative Name	Polyclonal Antibody to 8-Oxoguanine-DNA glycosylase (human), anti-OGG1
Appearance	Contains 0.05% sodium azide.
Storage Temp	+4°C

Antiserum to 8-Oxoguanine-DNA glycosylase Product Number: O-1078
Price	Price	Qty	Add to Cart
1x100 μl	$199.00

Product Number	C-1561
CAS #	CAS[25425-12-1]
Chemical Formula	C₂₃H₃₀O₆
Alternative Name	Citreoviridin A
Appearance	Orange-yellow powder
Melting Point	110ºC
Molecular Weight	M.W. 412
Purity	Purity: ≥97%
Solubility	Soluble in benzene, ethanol, chloroform, ether, dichloromethane. Barely soluble in water and hexane.
Storage Temp	-20ºC

Citreoviridin, Penicillium sp. Product Number: C-1561
Price	Price	Qty	Add to Cart
1x1 mg	$58.00
1x5 mg	$220.00

Product Number	E-2030
CAS #	CAS[66701-25-5]
Chemical Name	trans-Epoxysucciny-L-leucyl-amido(4-guanidino) butane; (L-3-trans-Carboxyoxiran-2-Carbonyl)-L-Leucyl-Admat
Chemical Formula	C₁₅H₂₇N₅O₅
Alternative Name	E64
Appearance	White Solid
Molecular Weight	M.W. 357.4
Purity	Purity:>99%
Solubility	DMSO (25mg/ml) and H20 (20mg/ml)
Storage Temp	-20°C

MSDS Documentation: E-2030, E-64, MSDS COA Documentation: E-2030, B1549 E-2030, B1682 E-2030, C1175 E-2030, C1306 E-64 Product Number: E-2030
Price	Price	Qty	Add to Cart
1x5 mg	$45.00
1x25 mg	$180.00

Product Number	E-2022
Chemical Formula	C₂₄H₂₇N₉O₆. 2HCl . 2H₂O
Appearance	White solid
Molecular Weight	M.W. 537.5 . 73.0 . 36.0
Purity	Purity: ≥95% (HPLC)
Solubility	Soluble in water or DMSO
Storage Temp	-20°C

COA Documentation: E-2022, B1382 EB-47 . dihydrochloride. dihydrate Product Number: E-2022
Price	Price	Qty	Add to Cart
1x1 mg	$51.00
1x10 mg	$195.00

Product Number	C-1616
Chemical Name	Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone
Chemical Formula	C₁₀H₅F₃O₄O
Appearance	Yellow solid
Molecular Weight	M.W. 254.04
Purity	>98.0%
Solubility	Soluble in DMSO to 100 mM

FCCP Product Number: C-1616
Price	Price	Qty	Add to Cart
1x10 mg	$79.00
1x50 mg	$314.00

Product Number	I-2364
CAS #	5814-93-7
Chemical Name	Indole 3-propionamide
Chemical Formula	C₁₁H₁₂N₂O
Appearance	White solid
Molecular Weight	188.23
Purity	≥99% by GC
Solubility	DMSO
Storage Temp	-20°C

IPAM Product Number: I-2364
Price	Price	Qty	Add to Cart
1x100 mg	$55.00
1x500 mg	$195.00
1x1 g	$295.00

Product Number	N-1221
Chemical Name	[[5-(1,1-Dioxo-thiomorpholin-4-ylmethyl)-2-phenyl-1H-indol-7-yl]-(1-methanesulfonyl-piperidin-4-yl)-amine
Chemical Formula	C₂₅H₃₂N₄O₄S₂
Alternative Name	necrox-2
Appearance	Gray Powder
Molecular Weight	516.67
Purity	≥96%
Solubility	Soluble in DMSO (>10mg/ml)
Storage Temp	+4°C

Necrosis Inhibitor-2 Product Number: N-1221
Price	Price	Qty	Add to Cart
1x1 mg	$103.00
1x5 mg	$309.00

Product Number	N-1223
Chemical Name	[[5-(1,1-Dioxo-thiomorpholin-4-ylmethyl)-2-phenyl-1H-indol-7-yl]-(tetrahydro-pyran-4-ylmethyl)-amine
Chemical Formula	C₂₅H₃₁NO₃S.2CH₄O₃S
Alternative Name	Necrox-5
Appearance	Gray Powder
Molecular Weight	645.83
Purity	≥96%
Solubility	Soluble in DMSO (>10mg/ml) or distilled water (>10mg/ml)
Storage Temp	+4°C

COA Documentation: N-1223, D1059 Necrosis Inhibitor-5 Product Number: N-1223
Price	Price	Qty	Add to Cart
1x1 mg	$130.00
1x5 mg	$305.00

Product Number	P-2411
Alternative Name	Protein A, rProtein A, r-protein A, recombinant protein A, IgG purification, antibody purification, Protein A beads, Protein A sepharose, Protein A Sepharose Beads, proteina, protein-A, protein a, protein/a,
Appearance	Liquid
Molecular Weight	39.21 kDa
Purity	>98% by SDS-PAGE and HPLC
Storage Temp	-20oC or below. Stable, as supplied, for at least 1 year.

Protein A, Recombinant (Liquid Form) Product Number: P-2411
Price	Price	Qty	Add to Cart
1x10 mg	$80.00
1x25 mg	$185.00
1x100 mg	$595.00
1x1 g	$1,595.00

Product Number	P-2412
Alternative Name	proteina, protein-A, protein a, protein/a, Protein A, rProtein A, r-protein A, recombinant protein A, IgG purification, antibody purification, Protein A beads, Protein A sepharose, Protein A Sepharose Beads
Appearance	Lyophilized
Molecular Weight	39.21 kDa
Purity	>98% by SDS-PAGE and HPLC
Storage Temp	-20°C

Protein A, Recombinant (Lyophilized) Product Number: P-2412
Price	Price	Qty	Add to Cart
1x10 mg	$80.00
1x25 mg	$185.00
1x100 mg	$595.00
1x1 g	$1,595.00

Product Number	P-2416
Alternative Name	Proteinagl, protein-agl, protein agl, protein a/g/l, proteina/g/l, proteina/g/l, protein-agl, protein-a/g/l, protein a/g/l, protein/agl, Protein A/G/L, rProtein A/G/L, r-protein A/G/L, recombinant protein A/G/L, IgG purification, antibody purification, Pr
Appearance	Lyophilized
Molecular Weight	101.0 kDa
Purity	>98% by SDS-PAGE and HPLC
Storage Temp	-20°C

Protein A/G/L, Recombinant Product Number: P-2416
Price	Price	Qty	Add to Cart
1x1 mg	$95.00
1x5 mg	$275.00
1x25 mg	$965.00
1x100 mg	$2,950.00
1x1 g	$14,500.00

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