Angiogenesis

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Angiogenesis

Angiogenesis is the process of building new vasculature and is inherently coordinated with building new tissue. Increased angiogenesis is a distinguishing characteristic of cancer growth, as it indicates a tumor is developing or has developed its own blood supply. A.G. Scientific supplies a variety of reagents that can identify or inhibit angiogenesis. Our most popular are:

Thalidomide is an angiogenesis inhibitor, it inhibits TNF-alpha biosynthesis.

17-AAG is an ansamycin antibiotic which binds with a high affinity into the ATP binding pocket in Hsp90 and induces the degradation of proteins.

Fumagillin is an inhibitor of endothelial cell proliferation and is currently being investigated as potential treatment of intestinal microsporidiosis.

Geldanamycin is a benzoquinone ansamycin antibiotic which binds to Hsp90 (Heat Shock Protein 90) and alters it function.

A.G. Scientific delivers quality assured reagents directly to scientists, from small-scale to bulk orders. Our leadership in bulk supply allows us to provide custom product packaging and create multiple product forms. We offer “just in time” delivery, private labeling, and custom formulations for specific research needs.

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(±)-Thalidomide

Product Number: T-1020

Product Name	Price	Qty
(±)-Thalidomide - 1x100 mg	$102.00
(±)-Thalidomide - 1x500 mg	$410.00

Inhibits TNF-α biosynthesis. Angiogenesis inhibitor. Learn More

17-AAG

Product Number: A-1256

Product Name	Price	Qty
17-AAG - 1x500 μg	$50.00
17-AAG - 1x1 mg	$70.00
17-AAG - 1x5mg	$185.00

17-AAG is an ansamycin antibiotic which acts as an anti-tumor agent. Specifically, 17-AAG binds and inhibits Hsp90 (Heat shock protein 90). Learn More

17DMAG

Product Number: A-1298

Product Name	Price	Qty
17DMAG - 1x1mg	$70.00
17DMAG - 1x5 mg	$185.00

A semi-synthetic derivate of Geldanamcyin, 17-DMAG binds to Hsp90 and alters its function. A water soluble & cell-permeable analog of Gelda Learn More

2-Phthalimidino-glutaric acid

Product Number: P-1187

Product Name	Price	Qty
2-Phthalimidino-glutaric acid - 1x5 mg	$60.00

Stable analog of Thalidomide with increased anti-tumor potency. Learn More

AG 1385

Product Number: A-1170

Product Name	Price	Qty
AG 1385 - 1x1 mg	$55.00
AG 1385 - 1x5 mg	$158.00

Learn More

AG 1433

Product Number: A-1168

Product Name	Price	Qty
AG 1433 - 1x1 mg	$35.00
AG 1433 - 1x5 mg	$98.00

Potent and specific inhibitor of PDGF-b receptor kinase (IC50 = 5.0 μm) and Flk-1/KDR (IC50 = 9.3 μm). Also acts as an angiogenesis inhibi Learn More

Antiserum to-Epithelial Monocyteactivating Polypeptide II (EMAP II)(Human)

Product Number: E-2008

Product Name	Price	Qty
Antiserum to-Epithelial Monocyteactivating Polypeptide II (EMAP II)(Human) - 1x100 μg	$255.00

Specificity: Reacts with human EMAP II, EMAP II is specifically induced by apoptosis. Application: ELISA. Endothelial Monocyte Activating Po Learn More

Borrelidin, Streptomyces sp.

Product Number: B-1260

Product Name	Price	Qty
Borrelidin, Streptomyces sp. - 1x1mg	$237.00

Borrelidin, an 18-membered macrolide-polyketide, is a compound with anti-viral, anti-bacterial, anti-malarial, and anti-angiogenic propertie Learn More

COMP, Rat: Angiopoietin-1, Soluble, Human, Recombinant

Product Number: A-1304

Product Name	Price	Qty
COMP, Rat: Angiopoietin-1, Soluble, Human, Recombinant - 1x10 ug	$368.00
COMP, Rat: Angiopoietin-1, Soluble, Human, Recombinant - 1x50 ug	$990.00

Induces phosphorylation of Tie-2 in primary cultured human and mouse vascular endothelial cells. More potent than native Ang-1. The fibrinog Learn More

Cytochalasin E, Aspergillus clavatus

Product Number: C-1197

Product Name	Price	Qty
Cytochalasin E, Aspergillus clavatus - 1x1 mg	$38.00
Cytochalasin E, Aspergillus clavatus - 1x5 mg	$150.00
Cytochalasin E, Aspergillus clavatus - 1x10 mg	$275.00

A fungal metabolite that inhibits angiogenesis & tumor growth. Enhances PKC-dependent process of secretion. Does not inhibit glucose transpo Learn More

Dimethyloxallyl glycine

Product Number: D-1298

Product Name	Price	Qty
Dimethyloxallyl glycine - 1x10 mg	$65.00
Dimethyloxallyl glycine - 1x50 mg	$260.00

Cell permeable, competitive inhibitor of PHDs (prolyl hydroxylase domain-containing proteins; HIF-PHs), which destructs HIF-1α when hydroxy Learn More

Fumagillin, Aspergillus fumigatus

Product Number: F-1028

Product Name	Price	Qty
Fumagillin, Aspergillus fumigatus - 1x1 mg	$75.00
Fumagillin, Aspergillus fumigatus - 1x5 mg	$250.00
Fumagillin, Aspergillus fumigatus - 1x10 mg	$450.00

Fumagillin is an inhibitor of endothelial cell proliferation and angiogenesis. Fumagillin is also being investigated as potential treatment Learn More

Geldanamycin, Streptomyces hygroscopicus

Product Number: G-1047

Product Name	Price	Qty
Geldanamycin, Streptomyces hygroscopicus - 1x500 μg	$40.00
Geldanamycin, Streptomyces hygroscopicus - 1x1mg	$65.00
Geldanamycin, Streptomyces hygroscopicus - 1x5 mg	$190.00

Geldanamycin is a benzoquinone ansamycin antibiotic which binds to Hsp90 (Heat Shock Protein 90) and alters it function. HSP90 client protei Learn More

Kuanoniamine C

Product Number: K-1052

Product Name	Price	Qty
Kuanoniamine C - 1x1 mg	$98.00

Isolated from the sponge Oceanapia spec. Inhibits proliferation of HCT, HeLa (IC50=5.1 μg/ml), and MOMO-MAC 6 (IC50=1.2 mg/ml) cell lines. Learn More

Monoclonal Antibody to-endoGlyx-1(Human) (H572)

Product Number: E-2012

Product Name	Price	Qty
Monoclonal Antibody to-endoGlyx-1(Human) (H572) - 1x100 μg	$305.00

Anti- EndoGlyx-1 may aid in the characterization and quantification of the angiogenic phase of solid tumors. Clone: H572. Isotyp: Mouse Ig Learn More

N-Oxalyl-D-alanine

Product Number: O-1102

Product Name	Price	Qty
N-Oxalyl-D-alanine - 1x10 mg	$80.00
N-Oxalyl-D-alanine - 1x50 mg	$240.00

Cell permeable, potent competitive inhibitor of factor inhibiting HIF (Hypoxia-inducible Factor) asparagine hydroxylase (FIH, IC50<0.4mM). D Learn More

N-Oxalyl-L-alanine

Product Number: O-1104

Product Name	Price	Qty
N-Oxalyl-L-alanine - 1x10 mg	$60.00
N-Oxalyl-L-alanine - 1x50 mg	$180.00

Cell permeable, competitive inhibitor of PHDs (prolyl hydroxylase domain-containing proteins; HIF-PHs). Less potent inhibitor of factor inhi Learn More

N-Oxalylglycine

Product Number: O-1006

Product Name	Price	Qty
N-Oxalylglycine - 1x10 mg	$40.00
N-Oxalylglycine - 1x50 mg	$120.00

Cell permeable, competitive inhibitor of PHDs (prolyl hydroxylase domain-containing proteins; HIF-PHs). Learn More

Radicicol, Humicola fuscoatra

Product Number: R-1130

Product Name	Price	Qty
Radicicol, Humicola fuscoatra - 1x1 mg	$60.00
Radicicol, Humicola fuscoatra - 1x5mg	$235.00

Radicicol, a macrocyclic antifungal antibitotic, has been shown to bind to a highly conserved pocket in the Hsp90 (heat shock protein 90) ch Learn More

Suramin. Hexasodium Salt

Product Number: S-1012

Product Name	Price	Qty
Suramin. Hexasodium Salt - 1x250 mg	$130.00
Suramin. Hexasodium Salt - 1x1 g	$305.00

P2x and P2y Purinergic receptor antagonist. Also shown to be an anti-parasitic and anti-tumor agent. Inhibits angiogenesis. Learn More

Thiolutin, Streptomyces luteosporeus

Product Number: T-1226

Product Name	Price	Qty
Thiolutin, Streptomyces luteosporeus - 1x1 mg	$60.00
Thiolutin, Streptomyces luteosporeus - 1x5 mg	$235.00

Thiolutin is a sulfur-containing antibiotic, which is a potent inhibitor of bacterial and yeast RNA polymerases. It was found to inhibit in Learn More

Tie-2 Inhibitor 13

Product Number: T-1182

Product Name	Price	Qty
Tie-2 Inhibitor 13 - 1x1 mg	$110.00

Potent and cell permeable Tie-2 inhibitor (IC50=600nm). Learn More

Tranilast

Product Number: T-1048

Product Name	Price	Qty
Tranilast - 1x10 mg	$120.00
Tranilast - 1x50 mg	$480.00

Inhibitor of VEGF-induced angiogenesis. Also anti-allergic agent. Learn More