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Angiogenesis
tranilast
Image courtesy of Public Library of Science publication.  
Breast Cancer Stem-Like Cells Are Inhibited by a Non-Toxic Aryl Hydrocarbon Receptor Agonist from researchers at Department of Laboratory Medicine and Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Canada, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada. Treatment of MDA-MB-231 cell line with Tranilast reduces mammosphere formation and stem cell marker expression.

Angiogenesis is the process of building new vasculature and is inherently coordinated with building new tissue. Increased angiogenesis is a distinguishing characteristic of cancer growth, as it indicates a tumor is developing or has developed its own blood supply. AG Scientific supplies a variety of reagents that can identify or inhibit angiogenesis.  Our most popular are:

  • Thalidomide is an angiogenesis inhibitor, it inhibits TNF-alpha biosynthesis.
  • 17-AAGis an ansamycin antibiotic which binds with a high affinity into the ATP binding pocket in Hsp90 and induces the degradation of proteins.
  • Fumagillin is an inhibitor of endothelial cell proliferation and is currently being investigated as potential treatment of intestinal microsporidiosis.
  • Geldanamycin is a benzoquinone ansamycin antibiotic which binds to Hsp90 (Heat Shock Protein 90) and alters it function.

 

AG Scientific delivers quality assured reagents directly to scientists, from small-scale to bulk orders. Our leadership in bulk supply allows us to provide custom product packaging and create multiple product forms. We offer “just in time” delivery, private labeling, and custom formulations for specific research needs.

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  • Product Number: S-2096

    A potent inhibitor of Src-family protein tyrosine kinases. Inquire for more details, pricing & lead time.