![Borrelidin | CAS [7184-60-3] | anti-angiogenesis | Borrelidin, an 18-membered macrolide-polyketide, is a compound with anti-viral, anti-bacterial, anti-malarial, and anti-angiogenic properties. Offered by A.G. Scientific.](http://www.agscientific.com/media/catalog/product/cache/1/thumbnail/56x/5e06319eda06f020e43594a9c230972d/placeholder/default/iso9001_4.gif "Borrelidin | CAS [7184-60-3] | anti-angiogenesis | Borrelidin, an 18-membered macrolide-polyketide, is a compound with anti-viral, anti-bacterial, anti-malarial, and anti-angiogenic properties. Offered by A.G. Scientific.")
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Product Description
Borrelidin, an 18-membered macrolide-polyketide, is a compound with anti-viral, anti-bacterial, anti-malarial, and anti-angiogenic properties. It is a known inhibitor of bacterial and eukaryal threonyl-tRNA synthetases. Borrelidin induces apoptosis in endothelial cells via the caspase 3 and caspase 8 pathway. In addition, borrelidin strongly inhibits capillary tube formation and also disrupts formed capillary tubes by inducing apoptosis of the tube-forming cells in a rat aorta matrix culture model. In S.cerevisiae, borrelidin inhibits the cyclin-dependent kinase Cdc28/Cln2 with an IC50 of 24 μM, causing the arrest of both haploid and diploid cells in G1 phase and inducing the transcription of amino acid biosynthetic enzymes through a GCN4-dependent pathway.
Seeking published researchers utilizing our Borrelidin product? Hit the hot link for the full paper.
1. Role of antibiotic ligand in nascent peptide-dependent ribosome stalling, Nora Vázquez-Laslop, Dorota Klepacki, et al, Jun 2011; 108: 10496 - 10501.
Additional Information
COA Documentation: |
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| Product Number | B-1260 |
| CAS # | CAS [7184-60-3] |
| Chemical Name | 2-(7-Cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl)-cyclopentanecarboxylic acid |
| Chemical Formula | C28H43NO6 |
| Alternative Name | Borrelidine, Cyclopentanecarboxylic acid, NSC 216128, Treponemycin |
| Appearance | White to Off-white Powder |
| Molecular Weight | M.W. 489.7 |
| Purity | ≥98% ( HPLC) |
| Solubility | Soluble in DMSO, ethyl acetate, ethanol, DMF or methanol |
| Storage Temp | -20C |
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![Borrelidin | CAS [7184-60-3] | anti-angiogenesis | It is a known inhibitor of bacterial and eukaryal threonyl-tRNA synthetases. Borrelidin induces apoptosis in endothelial cells via the caspase 3 and caspase 8 pathway. Offered byA.G. Scientific.](http://www.agscientific.com/media/catalog/product/cache/1/image/5e06319eda06f020e43594a9c230972d/placeholder/default/iso9001_lg_1.gif "Borrelidin | CAS [7184-60-3] | anti-angiogenesis | It is a known inhibitor of bacterial and eukaryal threonyl-tRNA synthetases. Borrelidin induces apoptosis in endothelial cells via the caspase 3 and caspase 8 pathway. Offered byA.G. Scientific.")
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