Cytochalasin D is a cell-permeable fungal toxin, 10-fold more effective than Cytochalasin B. It binds to barbed end of actin filaments, inhibiting the association and dissociation of subunits. Cytochalasin D causes disruption of actin filaments, and inhibition of actin polymerization. It's not inhibit monosaccharide transport across cell membranes and also reported to exhibit antitumor activity, and induce apoptosis. It is isolated from Zygusporium mansonii. Also see Cytochalasin A (C-1111), B (C-1027), C (C-1200), or E(C-1197).
* Listed below are a few published articles demonstrating the use of our Cytochalasin D. Inquire for a full list of references.
The lateral mobility of NHE3 on the apical membrane of renal epithelial OK cells is limited by the PDZ domain proteins NHERF1/2, but is dependent on an intact actin cytoskeleton as determined by FRAP, Boyoung Cha, Anne Kenworthy, Rakhilya Murtazina, and Mark Donowitz, J. Cell Sci., Jul 2004; 117: 3353 - 3365.
Inhibition of Phagocytosis by Haemophilus ducreyi Requires Expression of the LspA1 and LspA2 Proteins, Merja Vakevainen, Steven Greenberg, and Eric J. Hansen, Infect. Immun., Oct 2003; 71: 5994 - 6003.