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Fluorescent Probes
Image courtesy of Public Library of Science publication. Bioluminescent Imaging of Trypanosoma brucei Shows Preferential Testis Dissemination Which May Hamper Drug Efficacy in Sleeping Sickness from researchers at Institute of Tropical Medicine Antwerp, Department of Parasitology, Antwerp, Belgium, Katholieke Universiteit Leuven, Deptartment of Biosystems, Leuven, Belgium, Karolinska Institute, Microbiology and Tumorbiology Center, Stockholm, Sweden, Laboratoire de Microbiologie Cellulaire et Moléculaire et Pathogénicité UMR/CNRS-5234, Université Victor Segalen Bordeaux II, Bordeaux, France. Peripheral blood lymphocytes treated with Coelenterazine was used to test for parasite toxicity using the WST-1 assay.
Fluorescent probes are a class of molecules used for cell exploration; they consist of a bioactive molecule and a flourophore. The bioactive molecule attaches to its receptor or protein and a specifically selected fluorophore absorbs a specific wavelength of energy, revealing complex structural components and regulatory mechanisms of cells. AG's most popular are:
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Caspases are a type of cysteine protease closely linked to the process of apoptosis, we have over 40 different caspases.
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Calmodulin (CaM) is a calcium-binding protein that can bind to and regulate a multitude of different protein targets. Cell permeable, very sensitive and specific chemiluminescence probe of the superoxide anion and peroxynitrite. Shows 20 times higher luminescence than coelenterazine short-term and long-term memory, nerve growth and the immune response.
AG Scientific delivers quality assured reagents directly to scientists, from small-scale to bulk orders. Our leadership in bulk supply allows us to provide custom product packaging and create multiple product forms. We offer “just in time” delivery, private labeling, and custom formulations for specific research needs.
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