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Protein Kinases

Protein kinases are a family of kinases that functionally change specific proteins via phosphorylation. Protein kinases are involved in the regulation of signal transduction and many other cellular pathways. Many researchers have had success with Calmodulins & Gelanamycin. 

Calmodulins(CaM) is a ubiquitous, calcium-binding protein that can bind to and regulate a multitude of different protein targets, thereby affecting many different cellular functions.

Geldanamycin is a benzoquinone ansamycin antibiotic which binds to Hsp90 (Heat Shock Protein 90) and alters it function. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, and oncogenesis. Geldanamycin binds with a high affinity into the ATP binding pocket in Hsp90 and induces the degradation of proteins.

A.G. Scientific delivers quality assured reagents directly to scientists, from small-scale to bulk orders. Our leadership in bulk supply allows us to provide custom product packaging and create multiple product forms. We offer “just in time” delivery, private labeling, and custom formulations for specific research needs.
 

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(S)-Roscovitine
Product Number: R-2022

Product Name Price Qty
(S)-Roscovitine - 1x1 mg
$40.00
the (S)-enantiomer of the potent cyclin-dependent kinase (cdk) inhibitor Roscovitine (#R1016). Potently inhibits p34cdc2/cyclin B kinase (IC Learn More

10z-Hymenialdisine
Product Number: H-1150

Product Name Price Qty
10z-Hymenialdisine - 1x500 μg
$185.00
Potent inhibitor of mitogen-activated protein kinase kinase-1, Inhibitor of G2 DNA damage checkpoint and cyclin-dependent kinases CDK1/cycli Learn More

3-O-Acetyl-11-keto-beta-boswellic acid, Boswellia serrata
Product Number: B-1265

Product Name Price Qty
3-O-Acetyl-11-keto-beta-boswellic acid, Boswellia serrata - 1x5 mg
$130.00
Boswellic acid derivative, which shows anti-tumor and anti-inflammatory activities. Potent non-redox, noncompetitive 5-lipoxygenase and topo Learn More

3-O-Acetyl-beta-boswellic acid, Boswellia sp.
Product Number: B-1263

Product Name Price Qty
3-O-Acetyl-beta-boswellic acid, Boswellia sp. - 1x1 mg
$45.00
3-O-Acetyl-beta-boswellic acid, Boswellia sp. - 1x5 mg
$178.00
Boswellic acid derivative, which shows anti-tumor and anti-inflammatory activities. Potent non-redox, non-competitive 5-lipoxygenase and top Learn More

5-Iodotubercidin, Itu
Product Number: I-1005

Product Name Price Qty
5-Iodotubercidin, Itu - 1x1 mg
$113.00
5-Iodotubercidin, Itu - 1x5 mg
$450.00
A potent and specific inhibitor of ERK2. Also adenosine kinase inhibitor. Learn More

6BIO , GSK-3 Inhibitor
Product Number: G-1247

Product Name Price Qty
6BIO , GSK-3 Inhibitor - 1x1 mg
$50.00
A cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC₅₀ = 5 nM). Inhibition of GSK by Learn More

9-Cyanopaullone
Product Number: C-1205

Product Name Price Qty
9-Cyanopaullone - 1x1 mg
$70.00
9-Cyanopaullone - 1x5 mg
$275.00
Paullones represent a novel class of small molecule cyclin-dependent kinase (CDK) inhibitors. 9-cyanopaullone is a potent inhibitor of CDK1/ Learn More

AG 1007
Product Number: A-1180

Product Name Price Qty
AG 1007 - 1x1 mg
$50.00
AG 1007 - 1x5 mg
$148.00

AG 1024
Product Number: A-1178

Product Name Price Qty
AG 1024 - 1x1 mg
$65.00
AG 1024 - 1x5 mg
$248.00
An inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor tyrosine kinase activity. Learn More

AG 1112
Product Number: A-1176

Product Name Price Qty
AG 1112 - 1x1 mg
$50.00
AG 1112 - 1x5 mg
$148.00

AG 126
Product Number: A-1208

Product Name Price Qty
AG 126 - 1x5 mg
$75.00

Reduces LPS-induced tyrosine phosphorylation of p42MAPK in murine peritoneal macrophages at 50 µM.  At 100uM does not inhibi Learn More

AG 1288
Product Number: A-1192

Product Name Price Qty
AG 1288 - 1x10 mg
$71.00
AG 1288 - 1x50 mg
$275.00

Tyrosine kinase inhibitor reported to block TNFα induced cytotoxicity.  Also blocks glucocorticoid-induced COX-2 activity in human amn Learn More

AG 1295
Product Number: A-1188

Product Name Price Qty
AG 1295 - 1x1 mg
$30.00
AG 1295 - 1x5 mg
$80.00

AG 1296
Product Number: A-1174

Product Name Price Qty
AG 1296 - 1x5 mg
$103.00
Selective inhibitor of platelet-derived growth factor (PDGF) receptor protein. Learn More

AG 1385
Product Number: A-1170

Product Name Price Qty
AG 1385 - 1x1 mg
$55.00
AG 1385 - 1x5 mg
$158.00

AG 1433
Product Number: A-1168

Product Name Price Qty
AG 1433 - 1x1 mg
$35.00
AG 1433 - 1x5 mg
$98.00
Potent and specific inhibitor of PDGF-b receptor kinase (IC50 = 5.0 μm) and Flk-1/KDR (IC50 = 9.3 μm). Also acts as an angiogenesis inhibi Learn More

AG 1478
Product Number: A-1296

Product Name Price Qty
AG 1478 - 1x1 mg
$30.00
AG 1478 - 1x5 mg
$80.00

AG 1517, PD 153035
Product Number: P-1237

Product Name Price Qty
AG 1517, PD 153035 - 1x5 mg
$84.00
AG 1517, PD 153035 - 1x25 mg
$328.00
A tyrosine kinase inhibitor. Also inhibits Epidermal Growth Factor. Learn More

AG 183
Product Number: A-1206

Product Name Price Qty
AG 183 - 1x5 mg
$55.00
AG 183 - 1x25 mg
$158.00

AG 34
Product Number: A-1212

Product Name Price Qty
AG 34 - 1x1 mg
$35.00
AG 34 - 1x5 mg
$98.00

AG 370
Product Number: A-1186

Product Name Price Qty
AG 370 - 1x2 mg
$90.00
AG 370 - 1x10 mg
$365.00
Inhibitor of platelet derived growth factor (PDGF) autophosphorylation and PDGF-induced mitogenesis. Learn More

AG 490
Product Number: A-1164

Product Name Price Qty
AG 490 - 1x10 mg
$70.00
AG 490 - 1x50 mg
$285.00
Selectively inhibits CDK2 activation leading to a potent cell cycle arrest at late G1 and S phase. Cell permeable inhibitor of JAK-2 tyrosin Learn More

AG 494
Product Number: A-1166

Product Name Price Qty
AG 494 - 1x10 mg
$60.00
AG 494 - 1x50 mg
$245.00
Blocks CDK2 activation and causes cells to arrest at late G1 and during S phase.  Potent inhibitor of EGF receptor autophosphorylation (IC< Learn More

AG 527
Product Number: A-1214

Product Name Price Qty
AG 527 - 1x5 mg
$25.00
AG 527 - 1x25 mg
$90.00

AG 528
Product Number: A-1204

Product Name Price Qty
AG 528 - 1x5 mg
$30.00
AG 528 - 1x25 mg
$85.00

AG 537
Product Number: A-1202

Product Name Price Qty
AG 537 - 1x5 mg
$65.00
AG 537 - 1x25 mg
$189.00
Competitively inhibits EGF receptor kinase autophosphorylation. Learn More

AG 658
Product Number: A-1200

Product Name Price Qty
AG 658 - 1x1 mg
$30.00
AG 658 - 1x5 mg
$95.00

AG 698
Product Number: A-1218

Product Name Price Qty
AG 698 - 1x5 mg
$30.00
AG 698 - 1x25 mg
$85.00

AG 808
Product Number: A-1184

Product Name Price Qty
AG 808 - 1x5 mg
$45.00
AG 808 - 1x25 mg
$128.00

AG 82
Product Number: A-1210

Product Name Price Qty
AG 82 - 1x5 mg
$35.00
AG 82 - 1x25 mg
$100.00

AG 825
Product Number: A-1182

Product Name Price Qty
AG 825 - 1x2 mg
$70.00
AG 825 - 1x10 mg
$280.00
Selective inhibitor of HER2 compared to HER1 (IC50=0.35uM vs. 19uM for EGFR and 40uM for PDGFR). Learn More

AG 835
Product Number: A-1216

Product Name Price Qty
AG 835 - 1x5 mg
$25.00
AG 835 - 1x25 mg
$90.00

AG 879
Product Number: A-1198

Product Name Price Qty
AG 879 - 1x5 mg
$75.00
Inhibitor of NGF receptor (pp140c-trk) autophosphorylation selectivity without inhibiting EGF or PDGF receptor phosphorlyation (I Learn More

AG 957
Product Number: A-1196

Product Name Price Qty
AG 957 - 1x1 mg
$35.00
AG 957 - 1x5 mg
$100.00

AG 974
Product Number: A-1194

Product Name Price Qty
AG 974 - 1x1 mg
$35.00
AG 974 - 1x5 mg
$100.00

AICA Riboside
Product Number: A-1418

Product Name Price Qty
AICA Riboside - 1x50mg
$104.00

Alsterpaullone
Product Number: A-1136

Product Name Price Qty
Alsterpaullone - 1x1 mg
$58.00
Alsterpaullone - 1x5 mg
$265.00
Paullones represent a novel class of small molecule cyclin-dependent kinase (CDK) inhibitors. Alsterpaullone is a potent inhibitor of CDK1/c Learn More

Aminogenistein
Product Number: A-1106

Product Name Price Qty
Aminogenistein - 1x1 mg
$218.00
Inhibits the Protein-Tyrosine Kinase Activity of p56lck. Learn More

Anisomycin, Streptomyces griseolus
Product Number: A-1049

Product Name Price Qty
Anisomycin, Streptomyces griseolus - 1x100 mg
$160.00
Anisomycin, Streptomyces griseolus - 1x500 mg
$595.00
Anti-fungal antibiotic which inhibits Protein Synthesis. Also activates p54, MAP Kinases and Stress-Activated Protein Kinases. Used in Marti Learn More

Bisindolylmaleimide IV
Product Number: B-1295

Product Name Price Qty
Bisindolylmaleimide IV - 1x1 mg
$45.00
Bisindolylmaleimide IV - 1x5 mg
$145.00
A cell permeable potent and selective inhibitor of protein kinase C (IC₅₀ = 87 nM) and protein kinase A (IC₅₀ = 2.7 µM). Refer to Learn More

Bisindolylmaleimide V
Product Number: B-1291

Product Name Price Qty
Bisindolylmaleimide V - 1x1 mg
$45.00
Bisindolylmaleimide V - 1x5 mg
$145.00
A cell-permeable negative control compound for protein kinase C inhibition studies (IC₅₀ >100 µM). Blocks the activation of mitogen-sti Learn More

Bohemine
Product Number: B-1283

Product Name Price Qty
Bohemine - 1x1 mg
$39.00
Bohemine - 1x5 mg
$118.00
Cell permeable inhibitor of CDK1 (IC ₅₀=1.1 µM) and CD2 (IC₅₀=600 nM). Arrests cell cycle in the G₁/S boundary and activates matu Learn More

Calmodulin, Porcine
Product Number: C-1431

Product Name Price Qty
Calmodulin, Porcine - 1x1 mg
$60.00
Mammalian calmodulin isolated from porcine brain is suitable for applications requiring active pure calmodulin. Learn More

Calmodulin, Porcine, Biotinylated
Product Number: C-1433

Product Name Price Qty
Calmodulin, Porcine, Biotinylated - 1x100 ug
$185.00
Biotinylated porcine brain calmodulin using NHS ester activated biotin with an 8 atom spacer arm. Learn More

Calmodulin, Porcine, Fluorescein
Product Number: C-1435

Product Name Price Qty
Calmodulin, Porcine, Fluorescein - 1x100 ug
$185.00
FITC labeled mammalian calmodulin. Learn More

Calmodulin, Porcine, Immobilized Agarose
Product Number: C-1439

Product Name Price Qty
Calmodulin, Porcine, Immobilized Agarose - 1x2 mL
$300.00
Mammalian calmodulin immobilized to aldehyde activated agarose at 1 mg per mL. Coupled at 5 mg per mL and useful for pull down experiments a Learn More

Calmodulin, Porcine, Rhodamine
Product Number: C-1437

Product Name Price Qty
Calmodulin, Porcine, Rhodamine - 1x100 ug
$185.00
Mammalian calmodulin labeled with NHS ester of rhodamine. Learn More

Calmodulin, Porcine, Thiolyated
Product Number: C-1438

Product Name Price Qty
Calmodulin, Porcine, Thiolyated - 1x100 ug
$180.00
Mammalian calmodulin isolated from porcine brain is suitable for applications requiring active pure calmodulin. SH GROUP/Protein Ratio: C Learn More

Calmodulin, Wheat (Triticum aestivum) & Porcine, Immobilized High Loading;
Product Number: C-1441

Product Name Price Qty
Calmodulin, Wheat (Triticum aestivum) & Porcine, Immobilized High Loading; - 1x200 μL
$245.00
Calmodulins immobilized via SH (wheat germ) and amino groups (porcine) to epoxy resin allowing multiple orientations of bound calmodulin for Learn More

Calmodulin, Wheat (Triticum aestivum), Biotinylated
Product Number: C-1423

Product Name Price Qty
Calmodulin, Wheat (Triticum aestivum), Biotinylated - 1x50 ug
$250.00
Wheat germ (Triticum aestivum) calmodulin (CaM) sequence is unique in that it contains cysteine at residue position 26 (Cys26). In contrast Learn More

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