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CJ-21058

CAS: 405072-57-3 Formula: C23H33NO4 MW: 387.5 Appearance: Off-white solid Purity: ≥98% (HPLC)
Hazardous

PRODUCT # SIZE LIST PRICE QUANTITY BUY NOW BULK INQUIRIES
C-2398 1 mg
$92.88
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5 mg
$371.52
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CJ-21058 isolated from Phoma sp. is a close analog of equisetin, a fungal toxin.

Equisetin differs only in having a hydrogen atom at C-4 position of CJ-21058. It is also known to show a broad range of biological activites such as antibacterial, anti-HIV, cytotoxicity and DNA binding properties. The striking structural similarities between CJ-21058 and qeuisetin as well as their potent antibacterial properties point towards a possible correlation between antibacterial and SecA inhibitory activities of these compounds.

CJ-21058 shows antibacterial activity against gram-positive multi-drug resistant bacteria such as Staphylococcus aureus and Enterococcus faecalis(MIC=5µg/ml) by inhibiting ATP-dependent translocation of precursor proteins across a bacterial cell membrane. But it has no activity against Streptococcus pyogenes and Escherichia coli

 

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Additional Information

Product # C-2398
CAS # 405072-57-3
Chemical Name (5R,Z)-3-(Hydroxy((1R,2S,6S,8aS)-1,3,6-trimethyl-2-((E)-prop-1-en-1-yl)-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl)methylene)-5-(hydroxymethyl)-1-methylpyrrolidine-2,4-dione
Formula C23H33NO4
MW 387.5
Appearance Off-white solid
Purity ≥98% (HPLC)
Solubility Soluble in methylene chloride, DMSO or methanol
Storage Temp -20°C

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CJ-21058

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