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Chemokines (Greek -kinos, movement) are a family of small cytokines, or proteins secreted by cells. Their name is derived from their ability to induce directed chemotaxis in nearby responsive cells; they are chemotactic cytokines. Proteins are classified as chemokines according to shared structural characteristics such as small size (they are all approximately 8-10 kilodaltons in size), and the presence of four cysteine residues in conserved locations that are key to forming their 3-dimensional shape. However, these proteins have historically been known under several other names including the SIS family of cytokines, SIG family of cytokines, SCY family of cytokines, Platelet factor-4 superfamily or intercrines. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria, but none have been described for other invertebrates. These proteins exert their biological effects by interacting with G protein-linked transmembrane receptors called chemokine receptors, that are selectively found on the surfaces of their target cells.
FREE REVIEW ARTICLES
- Chemokines as Mediators of Neovascularization, Ellen C. Keeley, Borna Mehrad, et al. Chemokines as Mediators of Neovascularization. Arterioscler Thromb Vasc Biol, 2008; 28: 1928 - 1936.
- Chemokines and Cardiovascular Risk, Pål Aukrust, Bente Halvorsen, Arne Yndestad, et al. Chemokines and Cardiovascular Risk. Arterioscler Thromb Vasc Biol, 2008; 28: 1909 - 1919.
- Chemokines in Vascular Dysfunction and Remodeling, Andreas Schober. Chemokines in Vascular Dysfunction and Remodeling. Arterioscler Thromb Vasc Biol, 2008; 28: 1950 - 1959.