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Dorsomorphin, AMPK Inhibitor

DORSOMORPHIN, AMPK INHIBITOR
Product Number: D-1310

        

Details

Cell-permeable pyrrazolopyrimidine derivative that inhibits AMP kinase in an ATP-competitive manner. It displays no significant inhibition of ZAPK, SYKK, PKCT, PKA and JAK3. Decreases food intake in mice and inhibits the effects of AICAR and metformin. IT has been shown to inhibit BMP type I receptors ALK2, ALK3 and ALK6.

Additional Information

Alternate Name/Synonyms BML-275, Compound C, AMPK INHIBITOR
COA Documentation:
CHEMACX X1561649-0
Handling Protect from moisture.
Package ID Refrigerated
INDICATION Stroke
MDL NUMBER MFCD08705402
INCHI InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2
SMILES C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3
THERAPEUTIC AREA Neurological Disorders
USE A potent inhibitor of AMPK
Product Number D-1310
CAS # 866405-64-3
Chemical Name 6-[4-(2-Piperidin-1-yl)-ethoxy)- phenyl)]-3-pyridin-4-yl- pyrazolo[1,5-a]-pyrimidine
Chemical Formula C24H25N5O
Appearance Yellow Solid
Handling Protect from moisture.
Melting Point 244.93 °C
Molecular Weight 399.5
Purity 99%
Solubility Soluble in DMSO
Storage Temp -20°C

Dorsomorphin, AMPK Inhibitor

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  • Dorsomorphin | Compound C | CAS# 866405-64-3 | AMPK Inhibitor. Also inhibits BMP type I receptors ALK2, ALK3 and ALK6