![E-64 | E64 | CAS [66701-25-5] | Protease Inhibitor | E-64, Irreversible, potent and highly selective inhibitor of cysteine proteases. Does not affect cysteine residues in other enzymes. Offered in catalog & bulk quantities by A.G. Scientific.](http://www.agscientific.com/media/catalog/product/cache/1/thumbnail/56x/5e06319eda06f020e43594a9c230972d/E/-/E-2030_250x500_2.jpg "E-64 | E64 | CAS [66701-25-5] | Protease Inhibitor | E-64, Irreversible, potent and highly selective inhibitor of cysteine proteases. Does not affect cysteine residues in other enzymes. Offered in catalog & bulk quantities by A.G. Scientific.")
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Product Description
E-64 is an Irreversible, potent and highly selective inhibitor of cysteine proteases. Does not affect cysteine residues in other enzymes. Acts by forming a thioether bond with thiol of the active cysteine.
E-64 will not inhibit serine proteases (except trypsin) inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Specific active site titrant.
E-64 is a very useful cysteine protease inhibitor for use in in vivo studies because it has a specific inhibition; it is permeable in cells and tissues & has low toxicity. E-64 inhibits calpain, papain, and cathespin B, cathepsin L, bromelain, staphopain, collegenase and ficin.
The compound has been reported to inhibit intracellular Bax protease activity, and reduce oxidative stress, which includes a decrease in MDA levels, ICAM-1 expression and MOP activity. E-64 has also been used to study excystation (microbial cyst wall breaks down ) in Giardia lamblia. Effective concentration 1-10 uM.
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Additional Information
MSDS Documentation:COA Documentation: |
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| Product Number | E-2030 |
| CAS # | CAS[66701-25-5] |
| Chemical Name | trans-Epoxysucciny-L-leucyl-amido(4-guanidino) butane; (L-3-trans-Carboxyoxiran-2-Carbonyl)-L-Leucyl-Admat |
| Chemical Formula | C15H27N5O5 |
| Alternative Name | E-64 | E64 |
| Appearance | White Solid |
| Molecular Weight | M.W. 357.4 |
| Purity | Purity:>99% |
| Solubility | DMSO (25mg/ml) and H20 (20mg/ml) |
| Storage Temp | -20°C |
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