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E-64

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E-64

CAS: 66701-25-5 Formula: C15H27N5O5 MW: 357.4 Appearance: White Solid Purity: 99%
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PRODUCT # SIZE LIST PRICE QUANTITY BUY NOW BULK INQUIRIES
E-2030 5 mg
$48.03
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25 mg
$192.07
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E-64 is an Irreversible, potent and highly selective inhibitor of cysteine proteases. Does not affect cysteine residues in other enzymes. Acts by forming a thioether bond with thiol of the active cysteine. E-64 will not inhibit serine proteases (except trypsin) inhibits activation-induced programmed cell death and restores defective immune responses in HIV. Specific active site titrant.

E-64 inhibits calpain, papain, and cathepsin B, cathepsin L.The compound has been reported to inhibit intracellular Bax protease activity, and reduce oxidative stress, which includes a decrease in MDA levels, ICAM-1 expression and MOP activity. E-64 has also been used to study excystation in Giardia lamblia.

E-64 reduces inflammation in cystic fibrosis patients. E-64 plays a role in stabilizing the cytoskeleton protein Synaptopodin (Synpo),as well as, steadying signal transducer and activator of transcription-3 (STAT3). Studies suggest the potential use of STAT3 inhibitors in therapy of glomerular diseases.

 

 

Additional Information

Synonyms L-trans-Epoxysuccinyl-Leu-4-guanidinobutylamide, L-trans-Epoxysuccinyl-Leu-agmatine
Product # E-2030
CAS # 66701-25-5
Chemical Name trans-Epoxysucciny-L-leucyl-amido(4-guanidino) butane; (L-3-trans-Carboxyoxiran-2-Carbonyl)-L-Leucyl-Admat
Formula C15H27N5O5
MW 357.4
Appearance White Solid
Purity 99%
Solubility 15 mg/ml in 1:1 mixture water/ethanol
Storage Temp -20°C

Additional Information

MDL Number MFCD00080261
ChemACX X1036521-8
InChI InChI=1S/C15H27N5O5/c1-8(2)7-9(20-13(22)10-11(25-10)14(23)24)12(21)18-5-3-4-6-19-15(16)17/h8-11H,3-7H2,1-2H3,(H,18,21)(H,20,22)(H,23,24)(H4,16,17,19)/t9-,10-,11-/m0/s1
SMILES CC(C)C[C@@H](C(=O)NCCCCNC(=N)N)NC(=O)[C@@H]1[C@H](O1)C(=O)O

Additional Information

GHS Pictograms
RTECS RR0390000
Handling Protect from Light

Additional Information

msds 1 E-2030, SDS.pdf
Certificate of Analysis 1 E-2030, G1324.pdf
Certificate of Analysis 2 E-2030, G1278.pdf
Certificate of Analysis 3 E-2030, G1249.pdf
E-Brochure E-64 Inhibitor

Additional Information

E-64

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