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FK-506, Tacrolimus

FK-506, Tacrolimus

MSDS Documentation: F-1030_F-1030,_FK-506,_MSDS.pdf COA Documentation: F-1030_F-1030,_C1055.pdf F-1030_F-1030,_B1310.pdf FK-506, Tacrolimus Product Number: F-1030
Price	Price	Qty	Add to Cart
1x5 mg	$35.00
1x10mg	$55.00
1x25 mg	$132.00

Product Description

Tacrolimus, FK-506 or Fujimycin is an immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system and so lower the risk of organ rejection.
It is also used in a topical preparation in the treatment of atopic dermititis (eczema), severe refractory uveitis after bone marrow transplants, and the skin condition vitiligo.

Tacrolimus is chemically known as a macrolide. In T-cells, activation of the T-cell receptor normally increases intracellular calcium, which acts via calmodulin to activate calcineurin. Calcineurin then dephosphorylates the transcription factor NF-AT (nuclear factor of activated T-cells), which moves to the nucleus of the T-cell and increases the activity of genes coding for IL-2 and related cytokines. Tacrolimus prevents the dephosphorylation of NF-AT.
In detail, Tacrolimus reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin thus inhibiting both T-lymphotye signal transduction and IL-2 transcription. Although this activity is similar to cyclosporine, studies have shown that the incidence of acute rejection is reduced by tacrolimus use over cyclosporine.Although short-term immunosuppression concerning patient and graft survival is found to be similar between the two drugs, tacrolimus results in a more favorable lipid profile, and this may have important long-term implications given the prognostic influence of rejection on graft survival.

Attached are a few published references from researchers who have used our FK-506 product. We respectfully thank them for their trust in our product. Inquire for a full reference list.

.
1. Nobuko Hamasaki-Katagiriand James B. Ames. “Neuronal Calcium Sensor-1(Ncs1p) Is Up-regulated by Calcineurin to Promote Ca²⁺ **Tolerance in Fission Yeast*”** J BIOL. CHEM. 285: 4405–4414,(2010).

2. Frederick,R.L et al.” Yeast Miro GTPase, Gem1p, regulates mitochondrial morphology via a novel pathway”. J Cell Bio. 167: 87-98, (2004).
3. Joel Karwatsky et al, ‘Cholesterol efflux to apoA-I in ABCA1-expressing cells isregulated by Ca²⁺-dependent calcineurin signaling.” J Lipid Res.51: 1144-1156.(2010).

Seek researchers utilizing our FK-506 product?

Additional Information

MSDS Documentation: F-1030_F-1030,_FK-506,_MSDS.pdf COA Documentation: F-1030_F-1030,_C1055.pdf F-1030_F-1030,_B1310.pdf
Product Number	F-1030
CAS #	CAS [104987-11-3]
Chemical Formula	C₄₄H₆₉NO₁₂
Alternative Name	Tacrolimus, FR-900506, Prograf, Protopic
Appearance	Off-White Solid
Melting Point	MP: 119-121°C*
Merck Index	Merck Index: 13.9117.2001
Molecular Weight	M.W. 804.0
Preparation	Also reported to provide clear solution at >10mg/ml CH2CI2
Purity	Purity: ≥99%
Solubility	Soluble in DMSO, MeOH, also ETOAC.
Storage Temp	-20°C

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FK-506, Tacrolimus

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FK-506, Tacrolimus

MSDS Documentation:

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Product Description

Attached are a few published references from researchers who have used our FK-506 product. We respectfully thank them for their trust in our product. Inquire for a full reference list.

.
1. Nobuko Hamasaki-Katagiriand James B. Ames. “Neuronal Calcium Sensor-1(Ncs1p) Is Up-regulated by Calcineurin to Promote Ca²⁺ **Tolerance in Fission Yeast*”** J BIOL. CHEM. 285: 4405–4414,(2010).

2. Frederick,R.L et al.” Yeast Miro GTPase, Gem1p, regulates mitochondrial morphology via a novel pathway”. J Cell Bio. 167: 87-98, (2004).

3. Joel Karwatsky et al, ‘Cholesterol efflux to apoA-I in ABCA1-expressing cells isregulated by Ca²⁺-dependent calcineurin signaling.” J Lipid Res.51: 1144-1156.(2010).

Seek researchers utilizing our FK-506 product?

http://dev.biologists.org/content/133/16/3107.full.pdf+html

http://mcb.asm.org/content/30/10/2401.full.pdf+html

http://dev.biologists.org/content/133/16/3107.full.pdf+html

http://www.jlr.org/content/51/5/1144.full.pdf+html

http://www.jbc.org/content/285/7/4405.full.pdf+html

http://www.jimmunol.org/content/174/5/2720.full.pdf+html

http://www.jleukbio.org/content/86/2/337.full.pdf+html

http://www.jneurosci.org/content/27/48/13161.full.pdf+html

http://ajpcell.physiology.org/content/287/4/C971.full.pdf+html

http://www.jneurosci.org/content/29/48/15331.full.pdf+html

http://www.jbc.org/content/280/45/37526.full.pdf+html

http://www.jleukbio.org/content/86/2/205.full.pdf+html

http://www.jneurosci.org/content/27/21/5683.full.pdf+html

http://jcb.rupress.org/content/167/1/87.full.pdf+html

http://dev.biologists.org/content/133/16/3107.full.pdf+html

http://mcb.asm.org/content/27/2/633.full.pdf+html

http://jeb.biologists.org/content/211/7/1102.full.pdf+html

Additional Information

MSDS Documentation:

COA Documentation:

Notice

STILL COMPARING & NOT READY TO BUY? CLICK HERE FOR 10 % OFF YOUR NEXT PURCHASE.

Require bulk price at a PREFERRED DISCOUNT$$$? CLICK HERE.

Follow our latest scientific offerings WITH OUR DAILY BLOG. CLICK HERE.

All products sold by A.G. Scientific are strictly for Laboratory, Preclinical Research, or Bioprocessing purposes only. They are not intended for Human Drug, Food Additive, Clinical or Household use.

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FK-506, Tacrolimus

MSDS Documentation:

COA Documentation:

Product Description

Attached are a few published references from researchers who have used our FK-506 product. We respectfully thank them for their trust in our product. Inquire for a full reference list.

. 1. Nobuko Hamasaki-Katagiriand James B. Ames. “Neuronal Calcium Sensor-1(Ncs1p) Is Up-regulated by Calcineurin to Promote Ca2+ Tolerance in Fission Yeast*” J BIOL. CHEM. 285: 4405–4414,(2010).

2. Frederick,R.L et al.” Yeast Miro GTPase, Gem1p, regulates mitochondrial morphology via a novel pathway”. J Cell Bio. 167: 87-98, (2004).

3. Joel Karwatsky et al, ‘Cholesterol efflux to apoA-I in ABCA1-expressing cells isregulated by Ca2+-dependent calcineurin signaling.” J Lipid Res.51: 1144-1156.(2010).Seek researchers utilizing our FK-506 product?

Additional Information

MSDS Documentation:

COA Documentation:

Notice

Require bulk price at a PREFERRED DISCOUNT$$$? CLICK HERE.

Follow our latest scientific offerings WITH OUR DAILY BLOG. CLICK HERE.

All products sold by A.G. Scientific are strictly for Laboratory, Preclinical Research, or Bioprocessing purposes only. They are not intended for Human Drug, Food Additive, Clinical or Household use.

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.
1. Nobuko Hamasaki-Katagiriand James B. Ames. “Neuronal Calcium Sensor-1(Ncs1p) Is Up-regulated by Calcineurin to Promote Ca²⁺ **Tolerance in Fission Yeast*”** J BIOL. CHEM. 285: 4405–4414,(2010).

3. Joel Karwatsky et al, ‘Cholesterol efflux to apoA-I in ABCA1-expressing cells isregulated by Ca²⁺-dependent calcineurin signaling.” J Lipid Res.51: 1144-1156.(2010).

Seek researchers utilizing our FK-506 product?