You have no items in your shopping cart.
You're currently on:
Product Description
Over-activity of the epidermal growth factor receptor-associated tyrosine kinase (EGFR-TK) has been associated with a number of cancers and thus TK inhibitors could be potential therapeutic agents to prevent malignant growth. Gefitinib is a selective inhibitor of EGFR-TK inhibitor that blocks the growth of GEO colon cancer, ZR-75-1 and MCF-10A Ha-Ras breast cancer, and OVCAR-3 ovarian cancer cell lines with IC50s ranging between 0.2-0.4 μM. By interfering with the intracellular kinase domain, gefitinib prevents EGFR auto-phosphorylation and prevents downstream signal transduction. Gefitinib has been used to treat advanced (or recurrent) non-small cell lung cancer. However, the FDA retracted its general approval for this compound (Iressa™) when a phase III trial failed to demonstrate an overall survival benefit. Gefitinib appears to be most efficacious in treating certain EGFR gene mutations that are prevalent in Asian populations.
Additional Information
COA Documentation: |
|
| Product Number | C-1251 |
| CAS # | 184475-35-2 |
| Chemical Name | N-(3-chloro-4fluorophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]-4-quinazolinamine |
| Chemical Formula | C22H24ClFN4O3 |
| Alternative Name | Iressa™ |
| Appearance | A crystalline solid |
| Molecular Weight | 446.9 |
| Purity | ≥98% |
| Storage Temp | -20°C |
Notice
-
STILL COMPARING & NOT READY TO BUY? CLICK HERE FOR 10 % OFF YOUR NEXT PURCHASE.
-
Require bulk price at a PREFERRED DISCOUNT$$$? CLICK HERE.
-
Follow our latest scientific offerings WITH OUR DAILY BLOG. CLICK HERE.
All products sold by A.G. Scientific are strictly for Laboratory, Preclinical Research, or Bioprocessing purposes only. They are not intended for Human Drug, Food Additive, Clinical or Household use.
