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Geldanamycin | CAS [30562-34-6] | binds HSP90 | anti-tumor activity | A.G.Scientific, binds to Hsp90 (Heat Shock Protein 90) and exhibits potent antitumor activity

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Geldanamycin

CAS: 30562-34-6 Formula: C29H40N2O9 MW: 560.6 Appearance: Yellow Solid Purity: 98%
Hazardous

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G-1047 500 ug
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Geldanamycin is a benzoquinone ansamycin antibiotic which binds to Hsp90 (Heat Shock Protein 90) and alters it function. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, and oncogenesis.Cdc28 provides a molecular link between Hsp90, morphogenesis, and cell cycle progression inCandida albicans.Epidermal Growth Factor Receptors with Tyrosine Kinase Domain Mutations Exhibit Reduced Cbl Association, Poor Ubiquitylation, and Down-regulation but Are Efficiently Internalized.Inhibition of HSP90 in Trypanosoma cruzi Induces a Stress Response but No Stage Differentiation, Role of the Heat Shock Protein 90 in Immune Response Stimulation by Bacterial DNA and Synthetic Oligonucleotides.

Additional Information

Synonyms GA
Product # G-1047
CAS # 30562-34-6
Chemical Name [(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-HYDROXY-5,11,21-TRIMETHOXY-3,7,9,15-TETRAMETHYL-16,20,22-TRIOXO-17-AZABICYCLO[16.3.1]DOCOSA-1(21),8,12,14,18-PENTAEN-10-YL] CARBAMATE
Formula C29H40N2O9
MW 560.6
Appearance Yellow Solid
Purity 98%
Solubility Soluble in DMSO
Boiling Point 783.9±60.0 °C at 760 mmHg
Storage Temp -20°C
Therapeutic Area Oncological Disorders
Use Geldanamycin Analogue in Treating Patients With Colon Cancer

Additional Information

MDL Number MFCD00274570
ChemACX X1035747-8
InChI InChI=1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17+,22+,23+,24-,26+/m1/s1
SMILES C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)/C)OC)OC(=O)N)C)C)O)OC

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RTECS LX8920000
Handling Store in Tightly Sealed Vial Protect from Light

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msds 1 G-1047_G-1047,_Geldanamycin,_MSDS.pdf
Certificate of Analysis 1 G-1047, F1197B.pdf
Certificate of Analysis 2 G-1047, F1197A.pdf
Certificate of Analysis 3 G-1047, F1010B.pdf
E-Brochure Antibiotics Brochure

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Geldanamycin

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