Geldanamycin isolated from Streptomyces hygroscopicus is a benzoquinone ansamycin antibiotic which binds to Hsp90 (Heat Shock Protein 90) and alters it function.
HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, and oncogenesis.
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* Listed below are a few published articles demonstrating the use of our Geldanamycin. Inquire for a full list of references.
Epidermal Growth Factor Receptors with Tyrosine Kinase Domain Mutations Exhibit Reduced Cbl Association, Poor Ubiquitylation, and Down-regulation but Are Efficiently Internalized, David Padrón, et al., Cancer Res., Aug 2007; 67: 7695 - 7702.
Hydrogen sulfide protects SH-SY5Y cells against 6-hydroxydopamine-induced endoplasmic reticulum stress, Li Xie, et al., Am J Physiol Cell Physiol, Jul 2012; 303: C81 - C91.
Cdc28 provides a molecular link between Hsp90, morphogenesis, and cell cycle progression in Candida albicans, Heather Senn, et al., Mol. Biol. Cell, Jan 2012; 23: 268 - 283.