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Geldanamycin | CAS [30562-34-6] | binds HSP90 | anti-tumor activity | A.G.Scientific, binds to Hsp90 (Heat Shock Protein 90) and exhibits potent antitumor activity

GELDANAMYCIN
Product Number: G-1047

        

Details

Geldanamycin is a benzoquinone ansamycin antibiotic which binds to Hsp90 (Heat Shock Protein 90) and alters it function. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, and oncogenesis.Cdc28 provides a molecular link between Hsp90, morphogenesis, and cell cycle progression inCandida albicans.Epidermal Growth Factor Receptors with Tyrosine Kinase Domain Mutations Exhibit Reduced Cbl Association, Poor Ubiquitylation, and Down-regulation but Are Efficiently Internalized.Inhibition of HSP90 in Trypanosoma cruzi Induces a Stress Response but No Stage Differentiation, Role of the Heat Shock Protein 90 in Immune Response Stimulation by Bacterial DNA and Synthetic Oligonucleotides.

Additional Information

Alternate Name/Synonyms GA
MSDS Documentation:
COA Documentation:
MP/BOILING POINT 783.9±60.0 °C at 760 mmHg
CHEMACX X1035747-8
Handling Store in Tightly Sealed Vial Protect from Light
Package ID Refrigerated
INDICATION Colon Cancer
MDL NUMBER MFCD00274570
INCHI InChI=1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17+,22+,23+,24-,26+/m1/s1
SMILES C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)/C)OC)OC(=O)N)C)C)O)OC
THERAPEUTIC AREA Oncological Disorders
USE Geldanamycin Analogue in Treating Patients With Colon Cancer
Product Number G-1047
CAS # 30562-34-6
Chemical Name [(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-HYDROXY-5,11,21-TRIMETHOXY-3,7,9,15-TETRAMETHYL-16,20,22-TRIOXO-17-AZABICYCLO[16.3.1]DOCOSA-1(21),8,12,14,18-PENTAEN-10-YL] CARBAMATE
Chemical Formula C29H40N2O9
Appearance Yellow Solid
Handling Store in Tightly Sealed Vial Protect from Light
Molecular Weight 560.6
Purity 98%
RTECS LX8920000
Solubility Soluble in DMSO
Storage Temp -20°C

Geldanamycin | CAS [30562-34-6] | binds HSP90 | anti-tumor activity | A.G.Scientific, binds to Hsp90 (Heat Shock Protein 90) and exhibits potent antitumor activity

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  • geldanamycin 30562-34-6 Binds HSP90 shows Anti-Tumor Activity