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Hygromycin B concentrated solution, CAS [31282-04-9], Hygromycin B is used for the selection and maintenance of prokaryotic and eukaryotic cells transfected with the hygromycin resistance gene, hph.  A.G. Scientific

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Hygromycin B, Concentrated Solution

CAS: 31282-04-9 Formula: C20H37N3O13 MW: 527.53 Appearance: Concentrate Aqueous Solution (Fill Volume 2 ml) Purity: >90%

H-1012-MU 1 MU
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Hygromycin B is an aminoglycoside antibiotic isolated from Streptomyces hygroscopicus. It is commonly used to study protein synthesis. Aside from its efficacy against bacteria, fungi, and higher eukaryotic cells, hygromycin B is also an antiviral agent inhibiting translation upon selectively entering cells made permeable due to viral infection. It works as a standard selection antibiotic in gene experiments, especially for selection of hygromycin resistance gene transformed cells.

Aminoglycoside antibiotics are composed of amino groups attached to glycosides. They bind the 30s ribosomal subunit, causing misreading of the mRNA sequence and inhibition of translocation. Consequently, protein synthesis is inhibited.

Antibiotics are often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species.

Hygromycin's longstanding application as a gene selection antibiotic, has a powerful new role in Genome editing utilizing the CRISPR/Cas9 system1

CRISPR/Cas9: a molecular Swiss army knife for simultaneous introduction of multiple genetic modifications in Saccharomyces cerevisiae. 

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Additional Information

Product # H-1012-MU
CAS # 31282-04-9
Chemical Name O-6-Amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1-2-3)-O-β-D-talopyranosyl(1-5)-2-deoxy-N3-methyl-D-streptamine
Formula C20H37N3O13
MW 527.53
Appearance Concentrate Aqueous Solution (Fill Volume 2 ml)
Purity >90%
Solubility Soluble in Water
Boiling Point 897.6±65.0 °C at 760 mmHg
Storage Temp +4°C
Therapeutic Area Infectious Diseases
Use Hygromycin B is an antibiotic produced by the bacterium Streptomyces hygroscopicus. It is an aminoglycoside that kills bacteria, fungi

Additional Information

Merck Index 13.4878
MDL Number MFCD06795479
ChemACX X1009739-3
InChI InChI=1S/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/t5-,6+,7+,8-,9+,10-,11+,12-,13-,14-,15-,16+,17+,18-,19+,20?/m1/s1
SMILES CN[C@H]1C[C@H]([C@@H]([C@H]([C@@H]1O)O[C@H]2[C@@H]3[C@H]([C@H]([C@H](O2)CO)O)OC4(O3)[C@@H]([C@@H]([C@H]([C@H](O4)[C@H](CO)N)O)O)O)O)N

Additional Information

RTECS WK2130000
UN #'S UN 3462
Handling Warning.Toxic. May be Carcinogenic. May be Teratogenic. Wear gloves/mask when handling product.

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Certificate of Analysis 1 H-1012-MU, F1206D.pdf
Certificate of Analysis 2 H-1012-MU, F1206C.pdf
Certificate of Analysis 3 H-1012-MU, E1383D.pdf

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Hygromycin B, Concentrated Solution