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Hygromycin B concentrated solution, CAS [31282-04-9], Hygromycin B is used for the selection and maintenance of prokaryotic and eukaryotic cells transfected with the hygromycin resistance gene, hph.  A.G. Scientific

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Hygromycin B, Concentrated Solution

CAS: 31282-04-9 Formula: C20H37N3O13 MW: 527.53 Appearance: Concentrate Aqueous Solution (Fill Volume 2 ml) Purity: >90%
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H-1012-MU 1 MU
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Hygromycin B is an aminoglycoside antibiotic isolated from Streptomyces hygroscopicus. It is commonly used to study protein synthesis. Aside from its efficacy against bacteria, fungi, and higher eukaryotic cells, hygromycin B is also an antiviral agent inhibiting translation upon selectively entering cells made permeable due to viral infection. It works as a standard selection antibiotic in gene experiments, especially for selection of hygromycin resistance gene transformed cells.

Aminoglycoside antibiotics are composed of amino groups attached to glycosides. They bind the 30s ribosomal subunit, causing misreading of the mRNA sequence and inhibition of translocation. Consequently, protein synthesis is inhibited.

Antibiotics are often used in clinical in vitro tests known as antimicrobial susceptibility tests or ASTs to determine their efficacy against certain bacterial species.

Hygromycin's longstanding application as a gene selection antibiotic, has a powerful new role in Genome editing utilizing the CRISPR/Cas9 system1

http://femsyr.oxfordjournals.org/content/femsyr/15/2/fov004.full.pdf

CRISPR/Cas9: a molecular Swiss army knife for simultaneous introduction of multiple genetic modifications in Saccharomyces cerevisiae. 

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Additional Information

Product # H-1012-MU
CAS # 31282-04-9
Chemical Name O-6-Amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1-2-3)-O-β-D-talopyranosyl(1-5)-2-deoxy-N3-methyl-D-streptamine
Formula C20H37N3O13
MW 527.53
Appearance Concentrate Aqueous Solution (Fill Volume 2 ml)
Purity >90%
Solubility Soluble in Water
Boiling Point 897.6±65.0 °C at 760 mmHg
Storage Temp +4°C
Therapeutic Area Infectious Diseases
Use Hygromycin B is an antibiotic produced by the bacterium Streptomyces hygroscopicus. It is an aminoglycoside that kills bacteria, fungi

Additional Information

Merck Index 13.4878
MDL Number MFCD06795479
ChemACX X1009739-3
InChI InChI=1S/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/t5-,6+,7+,8-,9+,10-,11+,12-,13-,14-,15-,16+,17+,18-,19+,20?/m1/s1
SMILES CN[C@H]1C[C@H]([C@@H]([C@H]([C@@H]1O)O[C@H]2[C@@H]3[C@H]([C@H]([C@H](O2)CO)O)OC4(O3)[C@@H]([C@@H]([C@H]([C@H](O4)[C@H](CO)N)O)O)O)O)N

Additional Information

RTECS WK2130000
UN #'S UN 3462
PACKING GROUP I
Handling Warning.Toxic. May be Carcinogenic. May be Teratogenic. Wear gloves/mask when handling product.

Additional Information

Certificate of Analysis 1 H-1012-MU, F1206D.pdf
Certificate of Analysis 2 H-1012-MU, F1206C.pdf
Certificate of Analysis 3 H-1012-MU, E1383D.pdf

Additional Information

Citations
Rv2744c Is a PspA Ortholog That Regulates Lipid Droplet Homeostasis and Nonreplicating Persistence in Mycobacterium tuberculosis\nJ. Bacteriol. June 2016 198:11 1645-1661; Accepted manuscript posted online 21 March 2016
The MprB Extracytoplasmic Domain Negatively Regulates Activation of the Mycobacterium tuberculosis MprAB Two-Component System DJ Bretl, TM Bigley, SS Terhune, TC Zahrt - Journal of Bacteriology, 2014
Viral Bcl-2 Encoded by the Kaposi's Sarcoma-Associated Herpesvirus Is Vital for Virus Reactivation\nAnastasia Gelgor, Inna Kalt, Shir Bergson, Kevin F. Brulois, Jae U. Jung, and Ronit Sarid J. Virol., May 2015; 89: 5298 - 5307.
Reference Ergosterol content specifies targeting of tail-anchored proteins to mitochondrial outer membranes, Katrin Krumpe, Idan Frumkin, et al., Mol. Biol. Cell. Oct 2012. 23: 3927 - 3935.
Human Telomerase Reverse Transcriptase (hTERT) Is a Novel Target of the Wnt/β-Catenin Pathway in Human Cancer, Yong Zhang, LingLing Toh, et al. J. Biol. Chem. Sep 2012. 287: 32494 - 32511.
A Novel Downstream Regulatory Element Cooperates with the Silencing Machinery to Repress EPA1 Expression in Candida glabrata, Verónica Gallegos-García, Shih-Jung Pan, et al. Genetics. Apr 2012. 190: 1285 - 1297.
Recombinant human hyaluronidase Hyal-1: insect cells versus Escherichia coli as expression system and identification of low molecular weight inhibitors. Edith S.A. Hofinger et al. Glycobiology. 2007. 17: 444-453.

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Hygromycin B, Concentrated Solution

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