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Caspase & Granzyme B Inhibitors
Caspase inhibitors inhibit caspase activity. Caspases are a type of cysteine protease closely linked to the process of apoptosis (cell self-destruction). Existing in inactive forms within the cell, caspases are cleaved to become active enzymes upon the start of apoptosis.
Granzyme B inhibitors inhibit granzyme B activity. Granzyme B activates caspase (especially caspase-3) and also cleaves the factors like ICAD. It also cleaves many of the proteins lick Bid, which recruits the proteins Bax and Bak to change the membrane permeability of the mitochondria, causing the release of cytochrome c responsible for apoptosis in the absence of caspase activity.
AG Scientific can ship FedEx directly to your lab, from small-scale to bulk orders. Our leadership in bulk supply allows us to provide custom product packaging and create multiple product forms. We offer “just in time” delivery, private labeling, and custom formulations for specific research needs.