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Leptomycin B

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Leptomycin B

CAS: 87081-35-4 Formula: C33H48O6 MW: 540.7 Appearance: Liquid Purity: 98% by HPLC
Hazardous

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L-1069 100 ug
$96.04
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0.5 mg
$332.93
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2.5 mg
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Antibiotic that is used for studying nuclear localization and nuclear export. Specific inhibition of the CRM1/exportin1 nuclear export pathway. It also demonstrates anti-fungal anti-tumor activity.

Additional Information

Synonyms LMB, Elactocin, CI-940, CL-1957A, NSC-364372, PD-114720
Product # L-1069
CAS # 87081-35-4
Chemical Name (2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-17-ETHYL-6-HYDROXY-3,5,7,9,11,15-HEXAMETHYL-19-[(2S,3S)-3-METHYL-6-OXO-2,3-DIHYDROPYRAN-2-YL]-8-OXONONADECA-2,10,12,16,18-PENTAENOIC ACID
Formula C33H48O6
MW 540.7
Appearance Liquid
Purity 98% by HPLC
Solubility DMSO ( 25 mg/ml) or EtOH
Boiling Point 725.79 °C at 760 mmHg
Storage Temp -20°C
Therapeutic Area Infectious Diseases
Use Leptomycin B is an anti-funga antibiotic that is used for studying nuclear localization and nuclear export.

Additional Information

Merck Index Merck Index: 13.5463.2001
MDL Number MFCD06795848
ChemACX X1461547-9
InChI InChI=1S/C33H48O6/c1-9-28(14-15-29-24(5)13-16-31(36)39-29)19-22(3)12-10-11-21(2)17-25(6)32(37)27(8)33(38)26(7)18-23(4)20-30(34)35/h10-11,13-17,19-20,22,24-27,29,33,38H,9,12,18H2,1-8H3,(H,34,35)/b11-10+,15-14+,21-17+,23-20+,28-19-/t22-,24+,25-,26+,27-,29+,33-/m1/s1
SMILES CC/C(=C/[C@H](C)C/C=C/C(=C/[C@@H](C)C(=O)[C@@H](C)[C@@H]([C@@H](C)C/C(=C/C(=O)O)/C)O)/C)/C=C/[C@H]1[C@H](C=CC(=O)O1)C

Additional Information

UN #'S UN 1230
PACKING GROUP II
Handling Store in tightly Sealed Vial Protect from Light Packaged under inert gas. Product is toxic & flamable.

Additional Information

Certificate of Analysis 1 L-1069, G1211.pdf
Certificate of Analysis 2 L-1069_L-1069,_B1205.pdf
Certificate of Analysis 3 L-1069_L-1069,_B1766.pdf

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Leptomycin B

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