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Leupeptin, Hemisulfate

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Leupeptin, Hemisulfate

CAS: 103476-89-7 Formula: C20H38N6O4.0.5 H2SO4 MW: 475.6 Appearance: White to faint yellow powder Purity: >90% by HPLC, typically ~>96.0%
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L-1165 5 mg
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$255.00
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Leupeptin is a reversible competitive inhibitor of serine and thiol proteases. It has been reported to inhibit calpain, cathepsin B, cathepsins H and L and trypsin . A typical working concentrations is in the range of 10 to 100 µM. Leupeptin appears to be equally effective in any salt form, adjusting for equivalent peptide content. The hemisulfate salts were the first to be commercially available. Of the three salts, the hydrochloride is the least invasive form in biological settings. No problem or preference for the trifluoroacetate (TFA) form has been notes; TFA is volatile, so could possibly be removed by lyophilization.

Microbially produced leupeptin inhibitor was first isolated as a mixture of two very similar forms: acetyl-LeuLeu-Arg-al and propionyl-Leu-Leu-Arg-al. Although the propionyl leupeptin is active as an inhibitor the acetyl form is more commonly used and is available in several different forms.

Leupeptin, because of its aldehyde group, may act as a reducing agent and therefore interfere in protein determinations such as Lowry and, to a lesser extent, Bradford The activity of leupeptins and related analogs has been studied.

Leupeptin stock (20 mg/ml): Leupeptin in Methanol. Prepare a stock of 20 mg/ml in methanol, Store at -20°C.

Additional Information

Synonyms Ac-Leu-Leu-Arginal
Product # L-1165
CAS # 103476-89-7
Chemical Name Acetyl - Leu - Leu - Arg - al; Acetyl - L - leucyl - L - leucyl - L - argininal . hemisulfate
Formula C20H38N6O4.0.5 H2SO4
MW 475.6
Appearance White to faint yellow powder
Purity >90% by HPLC, typically ~>96.0%
Solubility Soluble in H20 (50mg/ml). Clear colorless to faint yellow solution
Storage Temp -20°C

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Hazard Image Yes

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msds 1 L-1165, SDS.pdf
Certificate of Analysis 1 L-1165, G1269.pdf
Certificate of Analysis 2 L-1165, G1022E.pdf
Certificate of Analysis 3 L-1165, G1022D.pdf
E-Brochure Leupeptin Hemisulfate Inhibitor

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Reference α-Actinin-4/FSGS1 is required for Arp2/3-dependent actin assembly at the adherens junction, Vivian W. Tang and William M. Brieher, J. Cell Biol. Jan 2012. 196: 115 - 130.
Agonist-induced Down-regulation of Endogenous Protein Kinase C α through an Endolysosomal Mechanism. J Abbotts et al. Biol. Chem. 2013.288:13093-13109.
Soluble HIV Tat Protein Removes the IL-7 Receptor α-Chain from the Surface of Resting CD8 T Cells and Targets It for Degradation. Elliott M. Faller et al. Journal of Immunology. Sept. 2010. 185: 2854-2866.
Heat Shock Proteins Regulate Activation-induced Proteasomal Degradation of the Mature Phosphorylated Form of Protein Kinase C. The Journal of Biological Chemistry. Sept. 2013. 288: 27112-27127.
FSGS3/CD2AP is a barbed-end capping protein that stabilizes actin and strengthens adherens junctions. Tang, V. W. and Brieher, W. J. Cell. Biol. Dec 2013. 203: 815-833.

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Leupeptin, Hemisulfate

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