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Memantine Hydrochloride

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Memantine Hydrochloride

CAS: 41100-52-1 Formula: C12H21N.HCl MW: 215.8 Appearance: White Powder Purity: 98%
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PRODUCT # SIZE LIST PRICE QUANTITY BUY NOW BULK INQUIRIES
M-1024 10 mg
$24.55
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50 mg
$69.36
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Memantine is a N-methyl-D-aspartate (NMDA) receptor antagonist, that stimulates dopamine release. Memantine hydrochloride (1-amino3, 5-dimethyladamantane hydrochloride) is a tricyclic amine chemically and pharmacologically related to the anti-viral prototype amantadine and its α-methyl derivative rimantadine.

Memantine is used in Parkinson’s disease and movement disorders. Memantine hydrochloride is currently known as the latest treatment for moderate-to-severe Alzheimer disease (AD). The drug acts by noncompetitively binding to the N-methyl d-aspartate (NMDA) receptors of neurons in brain tissue to prevent overstimulation by glutamate. When this excitatory neurotransmitter over activates NMDA receptors in a tonic manner, an excessive influx of neurotoxic calcium ions follows. The resultant excitotoxicity may play a role in the impairment of memory and cognition in AD. Because memantine has a low-to-moderate affinity for NMDA receptors, it does not seem to block normal glutamate transmission; rather, it reduces abnormal neurotransmitter-mediated activation of the receptors, thereby potentially reducing excitotoxic neuronal damage. This form of neuroprotection may explain the improved cognition in patients with AD. 

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Additional Information

Synonyms DMAA, D-145
Product # M-1024
CAS # 41100-52-1
Chemical Name 1-amino-3,5,dimethyladamantane.hydrochloride
Formula C12H21N.HCl
MW 215.8
Appearance White Powder
Purity 98%
Solubility Soluble in Ethanol
Boiling Point 239.8 °C at 760 mmHg
Storage Temp +20°C
Therapeutic Area Neurological Disorders
Use Memantine hydrochloride acts as an antagonist at the NMDA receptor, binding to the ion channel site. It stimulates dopamine release.

Additional Information

MDL Number MFCD00214336
ChemACX X1093464-4
InChI InChI=1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H
SMILES CC12CC3CC(C1)(CC(C3)(C2)N)C.Cl

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GHS Pictograms
RTECS YD1958750
Handling Store in Tightly Sealed Vial

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Certificate of Analysis 1 M-1024, G1056A.pdf

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Memantine Hydrochloride

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