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Image courtesy of Public Library of Science publication. Positive Regulation by GABABR1 Subunit of Leptin Expression through Gene Transactivation in Adipocytes from researchers at Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School of Natural Science and Technology, Kanazawa, Ishikawa, Japan. R3T3-L1 cells treated with Baclofen, a GABABR agonist, do not exhibit changes in adipcytic differentiation.
An agonist increases the signal transduction activity of a cell when bound to a receptor on that cell. It produces a conformational change that activates or increases activation of a second messenger inside the cell.
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