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Antibiotics
Antibiotics are essential in retaining the purity for a particular selection factor in a population of cells. Resistance to a variety of harmful antibiotics that interfere with desirable protein synthesis can be conferred through the use of cell culture products. A.G. Scientific has had particular success in the manufacture and supply of the following antibiotics.
- Hygromycin B is a standard antibiotic that selects for exclusively hygromycin resistant cells.
- Puromycin is an antibiotic that inhibits translation via premature chain termination; it is toxic to both prokaryotic and eukaryotic cells.
- Blasticidin kills both eukaryotic and prokaryotic cells by inhibiting peptide bond formation. Resistance to blasticidin occurs with expression of one of three genes: bsr, bls, or BDS.
- G418 inhibits polypeptide synthesis in prokaryotic and eukaryotic cells and is structurally related to gentamycin.
AG Scientific delivers quality assured antibiotics for gene selection and cell culture directly to scientists, from small-scale to bulk orders. Our leadership in bulk supply allows us to provide custom product packaging and create multiple product forms. We offer “just in time” delivery, private labeling, and custom formulations for specific research needs.
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