Image courtesy of Public Library of Science publication. Cytoplasmic Accumulation and Aggregation of TDP-43 upon Proteasome Inhibition in Cultured Neuronsfrom researchers at Laboratory for Translational Neurodegeneration, Brain & Mind Research Institute, University of Sydney, Sydney, Australia, Alzheimer's and Parkinson's Disease Laboratory, Brain & Mind Research Institute, University of Sydney, Sydney, Australia, Disciplines of Medicine and Pathology, University of Sydney, Sydney, Australia. Proteasome inhibition by lactacystin treatment induces cytoplasmic accumulation of TDP-43 (TAR DNA-binding protein 43) in primary neurons under various stress conditions.
Apoptosis is the process of programmed cell death. It is a normal and necessary phenomenon for many biological developmental processes, allowing cells to differentiate from each other and to form proper connections. It is also a critical phenomenon in aging and in healthy cell turnover; the healthy adult human body sheds tens of billions of cells each day in order to maintain homeostasis. Excessive or faulty apoptosis is associated with many human disorders such as neurodegenerative and auto-immune diseases and the proliferation of cancers. The machinery and signaling pathways that control cell life and death are key areas in human therapeutic research. AG Scientific is proud to offer products that can identify, inhibit or promote apoptosis.
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