Cytoskeletal

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Cytoskeletal

Proteins in the cytoplasm that provide structure to a cell are collectively known as the cytoskeleton. In addition to providing structure and protection to individual cells by acting as its musculature and skeleton, the cytoskeleton is involved in a cell’s mobility, division, organization, import and export.

Three categories of proteins comprise the cytoskeleton. These are actin filaments, intermediate filaments, and microtubules. AG has several reagents that target unique attributes of the cytoskeletal molecules, our most popular are:

Cytochalasins are fungal metabolites that inhibits angiogenesis & tumor growth. Enhances PKC-dependent process of secretion. Does not inhibit glucose transport

LY 294002 is a potent and specific cell-permeable inhibitor of phosphatidylinositol 3-kinase (PI3-Kinase).

AG Scientific delivers quality assured reagents directly to scientists, from small-scale to bulk orders. Our leadership in bulk supply allows us to provide custom product packaging and create multiple product forms. We offer “just in time” delivery, private labeling, and custom formulations for specific research needs.

FREE REVIEW ARTICLES

Spectraplakins: Master orchestrators of cytoskeletal dynamics, Kathleen C. Suozzi, Xiaoyang Wu, et al. Spectraplakins: Master orchestrators of cytoskeletal dynamics. J. Cell Biol, 2012; 197: 465 - 475.

Cytoskeletal dynamics in growth-cone steering, Sara Geraldo and Phillip R. Gordon-Weeks. Cytoskeletal dynamics in growth-cone steering. J. Cell Sci, 2009; 122: 3595 - 3604.

Microtentacles Tip the Balance of Cytoskeletal Forces in Circulating Tumor Cells, Michael A. Matrone, Rebecca A. Whipple, et al. Microtentacles Tip the Balance of Cytoskeletal Forces in Circulating Tumor Cells. Cancer Res, 2010; 70: 7737 - 7741.

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Product Number	I-1330
Chemical Name	Species Cross-Reactivity: Mam, Immunoglobulin isotype is unknown. Applications/Dilutions: ICC/IF (1/100 – 1/1,000), WB (1/500 – 1/2,500).
Appearance	0.2 ml with 50% glycerol, 0.01% sodium azide and 1.0 mg/ml BSA.
Solubility	Source: Mice were immunized with recombinant rat alpha-internexin.
Storage Temp	-20º C

Mouse Monoclonal Antibody-Neurofilament Alpha-Internexin/NF66 (2E3) Product Number: I-1330
Price	Price	Qty	Add to Cart
1x200 µl	$250.00

Product Number	N-1201
Chemical Name	Species cross-reactivity: Mam, Ck,Immunoglobulin isotype is IgG₁. Applications/dilutions: ICC/IF (1/100 – 1/500), WB (1/1,000 – 1/2,500).
Appearance	0.1 ml with 50% glycerol, 0.01% sodium azide and 1.0 mg/ml BSA.
Solubility	SOURCE: Mice were immunized with purified pig spinal cord NF-H.
Storage Temp	-20º C

Mouse Monoclonal Antibody-Neurofilament NF-H (Phosphorylated NAP4) Product Number: N-1201
Price	Price	Qty	Add to Cart
1x100 µl	$250.00

Product Number	N-1205
Chemical Name	Species cross-reactivity: Mam, Av, Immunoglobulin isotype is IgG₁. Applications/dilutions: ICC/IF (1/100 – 1/500), WB (1/500 – 1/2,500)
Appearance	0.2 ml with 50% glycerol, 0.01% sodium azide and 1.0 mg/ml BSA.
Solubility	SOURCE: Mice were immunized with enzymatically dephosphorylated pig neurofilament preparation.
Storage Temp	-20º C

Mouse Monoclonal Antibody-Neurofilament NF-L (DA2) Product Number: N-1205
Price	Price	Qty	Add to Cart
1x200 µl	$250.00

Product Number	N-1213
Chemical Name	Species cross-reactivity: Mam, Ck, Immunoglobulin isotype is IgG₁. Applications/dilutions: ICC/IF (1/25 – 1/100), WB (1/200 – 1/1,000).
Appearance	0.1 ml with 50% glycerol, 0.01% sodium azide and 1.0 mg/ml BSA.
Solubility	SOURCE: Mice were immunized with a recombinant polypeptide derived from the C-terminal 56 amino acid residues of rat NF-M.
Storage Temp	-20º C

Mouse Monoclonal Antibody-Neurofilament NF-M (3H11) Product Number: N-1213
Price	Price	Qty	Add to Cart
1x100 µl	$250.00

Product Number	M-1171
CAS #	CAS [122752-21-0]
Chemical Formula	C₅₂H₇₄N₄O₁₇
Appearance	White to Off White Solid.
Molecular Weight	M.W. 1027.2
Purity	Purity: ≥98%
Solubility	Soluble in DMSO or methanol.
Storage Temp	-20°C

Mycalolide B Product Number: M-1171
Price	Price	Qty	Add to Cart
1x20 μg	$268.00

Product Number	M-1233
CAS #	CAS [267402-71-1]
Chemical Name	9-Isopropyl-N2,N6-bis-(4-methoxybenzyl)-9H-purine-2,6-diamine
Chemical Formula	C₂₄H₂₈N₆O₂
Appearance	White Crystalline Solid
Molecular Weight	M.W.432.5
Purity	Purity:≥95% by HPLC
Solubility	DMSO (100 mg/ml)
Storage Temp	-20°C

Myoseverin Product Number: M-1233
Price	Price	Qty	Add to Cart
1x1 mg	$35.00
1x5 mg	$110.00

Product Number	N-1217
CAS #	733767-34-5
Chemical Formula	C₂₄H₃₅N₇.3HCl
Alternative Name	RAC 1 INHIBITOR
Appearance	White solid
Molecular Weight	530.97
Purity	≥ 98 %
Solubility	Soluble in water (100mM).
Storage Temp	-20°C

NSC-23766 Product Number: N-1217
Price	Price	Qty	Add to Cart
1x1 mg	$65.00

Product Number	O-1072
Alternative Name	rhOPG: Fc
Appearance	Lyophilized Powder. Contains PBS Buffer.
Preparation	Stable for at least 6 months when stored at -20°C. After reconstitution, prepare aliquots and store at -20°C.
Purity	Purity: ≥95%
Solubility	Reconstitute in Sterile Water.
Storage Temp	-20°C

Osteoprotegerin: Fc, Human, Recombinant. Product Number: O-1072
Price	Price	Qty	Add to Cart
1x50 μg	$340.00

Product Number	P-1651
Chemical Name	6-Amino-4-[(3-bromophenyl)amino]-7-(methylamino)quinazoline
Chemical Formula	C₁₅H₁₄BrN₅
Appearance	Yellow solid.
Molecular Weight	M.W.344.2
Purity	Purity:≥95%
Solubility	DMSO
Storage Temp	-20°C

PD 156273 Product Number: P-1651
Price	Price	Qty	Add to Cart
1x1 mg	$205.00

Product Number	P-1653
Chemical Name	4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline
Chemical Formula	C₁₇H₁₃BrN₄O
Appearance	Orange-yellow solid.
Molecular Weight	M.W.369.2
Purity	Purity:≥95%
Solubility	DMSO
Storage Temp	-20°C

PD 168393 Product Number: P-1653
Price	Price	Qty	Add to Cart
1x1 mg	$215.00

Product Number	P-1647
CAS #	CAS[216163-53-0]
Chemical Name	4-[(3-Bromophenyl)amino]-6-propionylamidoquinazoline
Chemical Formula	C₁₇H₁₅BrN₄O
Appearance	Yellow solid.
Molecular Weight	M.W.371.2
Purity	Purity:≥98%
Solubility	DMSO
Storage Temp	-20°C

PD 174265 Product Number: P-1647
Price	Price	Qty	Add to Cart
1x1 mg	$185.00

Product Number	G-1241
Chemical Name	Species cross-reactivity: Mam, Applications/Dilutions: CC/IF (1/1,000 – 1/10,000), WB (1/1,000 – 1/5,000)
Appearance	0.1 ml with 50% glycerol, 0.01% sodium azide and 1.0 mg/ml BSA.
Solubility	Source: Rabbits were immunized with recombinant purified bovine spinal cord GFAP.
Storage Temp	-20º C

Rabbit Polyclonal Antibody-Glial Fibrillary Acidic Protein (GFAP) Product Number: G-1241
Price	Price	Qty	Add to Cart
1x100 ul	$250.00

Product Number	L-1201
Chemical Name	Species cross-reactivity: Mam, Applications/dilutions: ICC/IF (1/100 – 1/2,500), WB (1/1,000 – 1/5,000)
Appearance	0.2 ml with 50% glycerol and 0.01% sodium azide.
Solubility	Source: Rabbits were immunized with a purified laminin-1 isolated from mouse EHS tumor.
Storage Temp	-20°C

Rabbit Polyclonal Antibody-Laminin-1 Product Number: L-1201
Price	Price	Qty	Add to Cart
1x200 ul	$250.00

Product Number	R-1110
Alternative Name	rhs RANKL, ODF, OPGL, TRANCE, Soluble, Human, Rec.
Appearance	Lyophilized powder. Contains PBS.
Preparation	Stable for at least 6 months when stored at -20°C.
Purity	Purity: ≥95%
Solubility	Soluble in Water.
Storage Temp	-20°C

RANKL, Soluble, Human, Rec. Product Number: R-1110
Price	Price	Qty	Add to Cart
1x10 μg	$360.00

Product Number	T-1186
CAS #	CAS [2799-07-7]
Chemical Formula	C₂₂H₂₁NO₂S
Alternative Name	NSC 83265
Appearance	White to off-white solid.
Molecular Weight	M.W. 363.5
RTECS	AY7710000
Solubility	Soluble in DMSO.
Storage Temp	-20°C

S-Trityl-L-cysteine Product Number: T-1186
Price	Price	Qty	Add to Cart
1x100 mg	$20.00
1x500 mg	$60.00

Product Number	S-1126
Chemical Formula	C₂₀H₁₉N₃O₂
Alternative Name	3[4-(1-Formylpiperazin-4-yl)benzylidenyl]-2-indolinone
Appearance	Orange to red crystalline solid.
Melting Point	MP: 276
Molecular Weight	M.W. 333.4
Purity	Purity: ≥98%
Solubility	Soluble in Acetone and DMSO
Storage Temp	-20°C

SU 4984 Product Number: S-1126
Price	Price	Qty	Add to Cart
1x1 mg	$82.00

Product Number	T-1184
CAS #	CAS [869304-55-2]
Chemical Name	(5R,11aS)-2-Benzyl-5-(3-hydroxyphenyl)-6H-1,2,3,5,11,11a-hexahydroimidazo[1,5-b]-beta-carboline-1,3-dione
Chemical Formula	C₂₆H₂₁N₃O₃
Appearance	Yellow solid.
Molecular Weight	M.W. 423.5
Purity	Purity: > 95%
Solubility	Soluble in DMSO (10mg/ml).
Storage Temp	-20°C

Trans-24 Product Number: T-1184
Price	Price	Qty	Add to Cart
1x1 mg	$80.00

Product Number	H-1182
CAS #	CAS [462630-41-7]
Chemical Formula	C₂₃H₂₃N₃O₃
Molecular Weight	M.W. 389.5
Purity	Purity: >95%
Solubility	Soluble in DMSO (10mg/ml).
Storage Temp	-20°C

COA Documentation: H-1182, B1408 trans-HR22C16 Product Number: H-1182
Price	Price	Qty	Add to Cart
1x1 mg	$105.00

Product Number	T-1134
Chemical Formula	C₂₂H₂₇N₃O₃
Appearance	White powder.
Molecular Weight	M.W. 381.5
Purity	Purity: ≥90%
Solubility	Soluble in methanol, 100% ethanol or DMSO.
Storage Temp	-20°C

Tryprostatin A Product Number: T-1134
Price	Price	Qty	Add to Cart
1x500 μg	$180.00

Product Number	U-1040
Chemical Formula	Recombinant Ubiquitin (corresponding to UniProt sequence P62988). The C-terminal glycine carboxyl is synthetically modified to an aldehyde.
Alternative Name	Ub-H
Appearance	Liquid, Aqueous solution containing .0.15M HCl.
Molecular Weight	M.W. 8.5 kDa
Preparation	Add directly to in vitro assay from the stock solution. Depending on conditions, typical concentrations for full inhibition in vitro are 2-5µM.
Purity	Purity: ≥95% (HPLC)
Solubility	Soluble and stable in aqueous solution at pH <7.0.
Storage Temp	+4°C

COA Documentation: U-1040_U-1040,_B1462,_r01.pdf Ubiquitin Aldehyde, (recombinant), synthetic Product Number: U-1040
Price	Price	Qty	Add to Cart
1x50 ug	$115.00

Product Number	V-1053
CAS #	CAS [143-67-9]
Chemical Formula	C₄₆H₅₈N₄O₉.H₂SO₄
Alternative Name	Vincaleukoblastine
Appearance	White Solid
Melting Point	MP: 211-216°C
Merck Index	Merck Index: 13.10044.2001
Molecular Weight	M.W. 909.1
Purity	Purity: >98%
Solubility	Soluble in water (25 mg/ml)
Storage Temp	-20°C

COA Documentation: V-1053, A9836 V-1053, C1259 Vinblastine Sulfate Product Number: V-1053
Price	Price	Qty	Add to Cart
1x5 mg	$60.00
1x25 mg	$220.00

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Cytoskeletal

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