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DNA Synthesis
etoposide
Image courtesy of Public Library of Science publication.  
Distinct Roles of Bcl-2 and Bcl-Xl in the Apoptosis of Human Bone Marrow Mesenchymal Stem Cells during Differentiation from researchers at INSERM, UMR 892, Équipe Labellisée «Ligue contre le Cancer», Nantes, France, Faculté de Médecine, Université de Nantes, Nantes, France, INSERM, UMR 643, Nantes, France, Cellular and Tissular Imaging Core Facility (MicroPICell), Université de Nantes, Nantes, France, INSERM, UMR 957, Nantes, France, Service de Physiologie Animale et Humaine, UFR Sciences et Techniques, Université de Nantes, Nantes, France. Etoposide treatment triggered an apoptotic change in conformation in Bax, a landmark of apoptosis, in human mesenchymal stem cells (hMSCs).

AG Scientific: A leader in DNA synthesis

DNA synthesis is the in vitro development of genes de novo. Specific genes can be developed with precise base pair arrangements, without use of the original DNA template.

AG Scientific delivers quality assured reagents directly to scientists, from small-scale to bulk orders. Our leadership in bulk supply allows us to provide custom product packaging and create multiple product forms. We offer “just in time” delivery, private labeling, and custom formulations for specific research needs.

 

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  • Product Number: W-1028

    Synthetic fluorescent bisintercalating anthracycline antibiotic with ultratight binding properties to DNA. Appears to overcome MRP-mediated

  • Product Number: W-1024

    *USE W-1028* Anti-cancer antibiotic that binds tightly to DNA. Appears to overcome MRP-mediated multidrug resistance.

  • Product Number: S-1094

    Mycotoxin that inhibits DNA synthesis. Induces sister chromatid exchanges in bone marrow cells of mice. Causes necrosis.

  • Product Number: S-2068

    Steffimycin B is a anthracycline metabolite isolated from a Streptomyces sp. displaying antibacterial and antineoplastic properties. Binding

  • Product Number: R-2026

    Resistoflavine is a rare, boat-shaped, pentacyclic polyketide isolated from several species of Streptomyces, often co-produced with resistom

  • Product Number: P-1266

    Proteinase K solution is a serine protease isolated fron the fungus, Triti

  • Product Number: P-1265

    Proteinase K is a non-specific serine protease u

  • Product Number: H-1170

    Source: Rabbit. Specificity: Recognizes human and mouse HDAC4. Polyclonal Antibody to Histone Deacetylase 4 (NT)

  • Product Number: H-1164

    Source: Rabbit. Specificity: Recognizes human, mouse, rat, hamster and dog HDAC2.  Detects band of ~ 55kDA by WB, also ~40kDa of unknown id

  • Product Number: H-1162

    Source: Rabbit. Specificity: Recognizes human, mouse, rat, hamster and dog HDAC1. Detects a band of ~62kDa by Western Blot. Polyclonal Antib

  • Product Number: P-1659

    Irreversible inhibitor of adenosine deaminase (Ki = 2.5 pM). Anticancer agent. Inquire for pricing & lead time.

  • Product Number: P-1179

    Antibiotic, Mycotoxin that induces DNA single-strand breaks. Anti-HIV Activity.

  • Product Number: O-1063

    Oligomycin A is a component of the oligomycin complex (O-1060). Oligomycin A inhibits mitochondrial ATPases (F1F0). St

  • Product Number: N-1215

     

  • Product Number: N-1180

    Inhibitor of HSP90. Novobiocin interacts with the C-terminal ATP-binding domain of HSP90, unlike 17-AAG (A1256), Geldanamycin (G1047), Herbi

  • Product Number: C-1541

    DESCRIPTION: the cdc6 protein, originally described in budding yeast (cdc6p), is essential and limiting for DNA synthesis. The protein funct

  • Product Number: C-1563

    DESCRIPTION: The cdc6 protein, originally described in budding yeast (cdc6p), is essential and limiting for DNA synthesis. The protein funct

  • Product Number: A-1276

    Immunogen: Recombinant human ACRP30. Clone: AX 773. Isotype: Mouse IgG1. Western blot analysis of human plasma ACRP30 with AX773 MAb at a co

  • Product Number: K-1052

    Isolated from the sponge Oceanapia spec. Inhibits proliferation of HCT, HeLa (IC50=5.1 μg/ml), and MOMO-MAC 6 (IC50=1

  • Product Number: I-1310

    iTransFect reagent is a liposome formulation developed for highly efficient transfection of Spodoptera frugiperda-derived insect cells (e.g.

  • Product Number: H-1178

    A fluorogenic substrate for histone deacetylase (HDAC). Ex(max): 330nm; Em(max): 395nm.

  • Product Number: F-1136

    Originally isolated from a marine sponge. Fascaplysin is selective CYCLIN-DEPENDENT KINASE 4 INHIBITOR (in a ATP competitive manner).

  • Product Number: E-2004

    Topoisomerase II inhibitor. Anti-tumor reagent. Widely used apoptosis

  • Product Number: C-1027

    A fungal metabolite that acts as a microtubule inhibitor. Also induce

  • Product Number: C-2376

    Ciprofloxican is a fluoroquinolone antibacterial

  • Product Number: C-1023

    Antibiotic produced by Streptomyces grieus that inhibits RNA synthesi

  • Product Number: C-1371

    Antitumor antibiotic which inhibits topoisomerase II. Induces single-strand scission in DNA in the presence of reducing agents.

  • Product Number: C-1261

    Inhibitor of nuclear topoisomerase I by binding to and trapping the t

  • Product Number: B-1247

     

  • Product Number: B-1271

    Nonsteroidal anti-androgen. Induces cell death by a pathway that is independent of changes in mitochondrial membrane potential and Bcl-2 act

  • Product Number: B-1249

    Antibiotic with high and selective activity against Staphylococcus strains including methicillin-resistant S. Aureus (MRSA) strains in a con

  • Product Number: A-1270

    Strong antibiotic activity against gm-positive bacteria and cytotoxicity. Shows inhibitory effects on cellular adhesion and anaphylatoxin re

  • Product Number: O-1080

    Source: Rabbit. Immunogen: Raised against complete O6-methylguanine-DNA methyltransferase of human origin. Specificity: Recognizes human MGM

  • Product Number: O-1078

    Source: Rabbit. Immunogen: Raised against 8-Oxoguanine-DNA glycosylase of human origin. Specificity: Recognizes hOGG1. Application: WB (in h

  • Product Number: A-1268

    Induces apoptosis, which is not prevented by the presence of bcl-2. Inhibits mitochondrial electron transport specifically between cytochrom

  • Product Number: A-1022

    An anti-neoplastic antibiotic that inhibits cell proliferation by for

  • Product Number: A-1132

    7-Amino-Actinomycin D is a Fluorescent DNA Stain. Binds Single strand

  • Product Number: A-2171

    5-Aza-2'-deoxycytidine is an epigenetic modifier. Decitabine is an analogue of the nucleoside 2’-deoxycytidine. 5-Aza-2'-deoxycytidine is

  • Product Number: H-1132

    A DNA topoisomerase I inhibitor. It induces apoptosis in human breast cancer cells. Inquire for pricing and lead time.

  • Product Number: R-2022

    the (S)-enantiomer of the potent cyclin-dependent kinase (cdk) inhibitor Roscovitine (#R1016). Potently inhibits p34cdc2/cyclin B kinase (IC

  • Product Number: A-1026

    Aphidicolin is a reversibl