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Product Description
FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclari as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 is phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1p) receptors. Down-regulation of S1P1 receptors on T and B lymphocytes by FTY720 results in defective egress of these cells from spleen, lymph nodes, and Peyer's patch. FTY720 also enhances the activity of the sphingosine transporter Abcb1 and the leukotriene C4 transporter Abcc1 and inhibits cystolic phospholipase A2 activity.
Additional Information
| Product Number | F-1162 |
| CAS # | [162359-56-O] |
| Chemical Formula | C19H33NO2.HCl |
| Appearance | Crystalline Solid |
| Molecular Weight | 343.9 |
| Purity | >98% |
| Solubility | Soluble in DMSO (10 mg / ml), 100% ethanol or Dimethyl formamide. |
| Storage Temp | -20°C |
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All products sold by A.G. Scientific are strictly for Laboratory, Preclinical Research, or Bioprocessing purposes only. They are not intended for Human Drug, Food Additive, Clinical or Household use.
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