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Oxidative Stress
Oxidative Stress is caused by an imbalance between the production of reactive oxygen and a biological system's ability to readily detoxify the reactive intermediates. This reducing environment is preserved by enzymes that maintain the reduced state through a constant input of metabolic energy. Disturbances in this normal redox state can cause toxic effects that can damage proteins, lipids, and DNA. Two of our more popular reagants are:
Radicicol is an antifungal antibiotic which acts as a Hsp90-specific inhibitor.
17-AAG is an ansamycin antibiotic which binds to Hsp90 (Heat Shock Protein 90) and alters it function. Hsp90 proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, and oncogenesis.
A.G. Scientific delivers quality assured reagents directly to scientists, from small-scale to bulk orders. Our leadership in bulk supply allows us to provide custom product packaging and create multiple product forms. We offer “just in time” delivery, private labeling, and custom formulations for specific research needs.
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