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Protein Kinases
AG Scientific: A leader in protein kinases.
Protein kinases are a family of kinases that functionally change specific proteins via phosphorylation. Protein kinases are involved in the regulation of signal transduction and many other cellular pathways. Many researchers have had success with Calmodulins & Gelanamycin.
- Calmodulins(CaM) is a ubiquitous, calcium-binding protein that can bind to and regulate a multitude of different protein targets, thereby affecting many different cellular functions.
- Geldanamycin is a benzoquinone ansamycin antibiotic which binds to Hsp90 (Heat Shock Protein 90) and alters it function. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, and oncogenesis. Geldanamycin binds with a high affinity into the ATP binding pocket in Hsp90 and induces the degradation of proteins.
AG Scientific delivers quality assured reagents directly to scientists, from small-scale to bulk orders. Our leadership in bulk supply allows us to provide custom product packaging and create multiple product forms. We offer “just in time” delivery, private labeling, and custom formulations for specific research needs.
FREE REVIEW ARTICLES
- Calcium/Calmodulin-Dependent Protein Kinase Kinase 2: Roles in Signaling and Pathophysiology, Luigi Racioppi and Anthony R Means. Calcium/Calmodulin-Dependent Protein Kinase Kinase 2: Roles in Signaling and Pathophysiology. J. Biol. Chem, 2012; 10.1074/jbc.R112.356485.
- AMP-activated protein kinase: An emerging drug target to regulate imbalances in lipid and carbohydrate metabolism to treat cardio-metabolic diseases, Rai Ajit K. Srivastava, Stephen L. Pinkosky, et al. AMP-activated protein kinase: An emerging drug target to regulate imbalances in lipid and carbohydrate metabolism to treat cardio-metabolic diseases. J. Lipid Res, 2012; 10.1194/jlr.R025882.
- Protein Kinase D Signaling: Multiple Biological Functions in Health and Disease, Enrique Rozengurt. Protein Kinase D Signaling: Multiple Biological Functions in Health and Disease. Physiology, 2011; 26: 23 - 33.
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