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MAP Kinase Pathway

The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5 that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signaling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.

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  1. (-)-Epigallocatechin gallate

    (-)-Epigallocatechin gallate

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    E-2002 989-51-5 50 mg
    $92.88
  2. 3-O-Acetyl-11-keto-Beta-boswellic acid, Boswellia serrata

    3-O-Acetyl-11-keto-Beta-boswellic acid, Boswellia serrata

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    B-1265 67416-61-9 5 mg
    $149.64
  3. Anisomycin | CAS 22862-76-6 | Anti-fungal antibiotic | AG Scientific

    Anisomycin

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    A-1049 22862-76-6 10 mg
    $41.30
    50 mg
    $106.30
    100 mg
    $175.45
    500 mg
    $630.00
  4. Apigenin

    Apigenin

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    A-1108 520-36-5 10 mg
    $37.26
    20 mg
    $78.43
    50 mg
    $111.87
    100 mg
    $304.44
  5. Aurintricarboxylic acid

    Aurintricarboxylic acid

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    A-2191 4431-00-9 1 g
    $77.40
  6. Biotinyl-ASTD-FMK

    Biotinyl-ASTD-FMK

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    B-2206 500 g
    $273.48
    1 mg
    $500.52
  7. CHIR-99021

    CHIR-99021

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    C-1702 252917-06-9 5 mg
    $201.24
    25 mg
    $717.24
  8. D4476

    D4476

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    C-2279 301836-43-1 1 mg
    $77.40
    5 mg
    $304.44
  9. Doramapimod

    Doramapimod

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    D-2294 285983-48-4 5 mg
    $77.40
    25 mg
    $294.12
  10. EMAP-II Inhibitor Z-ASTD-FMK

    EMAP-II Inhibitor Z-ASTD-FMK

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    E-2303 20 l (10mM)
    $201.24
  11. GSK-1120212

    GSK-1120212

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    G-2339 871700-17-3 1 mg
    $77.40
    5 mg
    $304.44
  12. Hypericin, Hypericum perforatum

    Hypericin, Hypericum perforatum

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    H-1042 548-04-9 1 mg
    $75.34
    5 mg
    $277.61
  13. Lovastatin

    Lovastatin

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    L-1043 75330-75-5 250 mg
    $0.00
    50 mg
    $90.82
  14. Mouse Monoclonal Antibody-cdc6 (Clone 6-36)

    Mouse Monoclonal Antibody-cdc6 (Clone 6-36)

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    C-1563 100 ug
    $258.00
  15. Mouse Monoclonal Antibody-cdc6 (Clone 6-37)

    Mouse Monoclonal Antibody-cdc6 (Clone 6-37)

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    C-1541 100 ug
    $258.00
  16. PAK1, kinase domain(recombinant human PAK1 kinjase domain)

    PAK1, kinase domain(recombinant human PAK1 kinjase domain)

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    P-1645 10 ug
    $366.36
  17. PAK2, kinase domain

    PAK2, kinase domain

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    P-1643 10 ug
    $366.36
  18. Parthenolide| CAS [20554-84-1]|Anti-inflammatory| Induces apoptosis Parthenolide has Anti-inflammatory, Anti-secretory and spasmolytic activity. It  induces apoptosis aka programmed cell death and the creation of reactive oxygen species (ROS).

    Parthenolide

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    P-1233 20554-84-1 50 mg
    $71.21
    250 mg
    $201.24
  19. PathwayReady MAP Kinase Signaling Inhibitor Panel

    PathwayReady MAP Kinase Signaling Inhibitor Panel

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    P-2383 7 inhibitors
    $562.44
  20. PD 184161

    PD 184161

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    P-1713 212631-67-9 5 mg
    $98.04
    10 mg
    $173.38
    25 mg
    $379.78
  21. PD 98059 EZSolution

    PD 98059 EZSolution

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    E-2314 167869-21-8 5 mg
    $98.04
  22. PD-98059

    PD-98059

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    P-1019 167869-21-8 5 mg
    $72.24
    10 mg
    $108.36
  23. Polyclonal Antibody to-BACE1

    Polyclonal Antibody to-BACE1

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    B-1253 0.2 mL
    $278.64
  24. Polyclonal Antibody to-BACE2

    Polyclonal Antibody to-BACE2

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    B-1255 0.2 mL
    $278.64
  25. Proteinase K 20mg/ml Solution

    Proteinase K 20mg/ml Solution

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    P-1266 2 ml
    $61.00
    5x 2 ml
    $225.00
    25 ml
    $325.00
  26. SB-202190

    SB-202190

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    S-1080 152121-30-7 1 mg
    $99.07
  27. SB-203580

    SB-203580

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    S-1014 152121-47-6 1 mg
    $84.62
    5 mg
    $330.24
  28. SB-203580 in Solution

    SB-203580 in Solution

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    S-1015 1 ml
    $205.37
  29. SH-6

    SH-6

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    S-2026 500 ug
    $249.74
    1 mg
    $497.42
  30. Tripolin A

    Tripolin A

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    T-2487 1148118-92-6 Inquire
    $0.00
  31. VX-702

    VX-702

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    V-2481 479543-46-9 1 mg
    $304.44
    5 mg
    $923.64
  32. Wortmannin

    Wortmannin

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    W-1022 19545-26-7 1 mg
    $51.60
    5 mg
    $154.80
    25 mg
    $603.72