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NF-κB Signaling

Nuclear factor-κB (NF-κB) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are several pathways leading to NF-kappa B-activation. The canonical pathway is induced by tumour necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1) or byproducts of bacterial and viral infections. This pathway relies on IKK- mediated IkappaB-alpha phosphorylation on Ser32 and 36, leading to its degradation, which allows the p50/p65 NF-kappa B dimer to enter the nucleus and activate gene transcription. Atypical pathways are IKK-independent and rely on phosphorylation of IkappaB-alpha on Tyr42 or on Ser residues in IkappaB-alpha PEST domain. The non-canonical pathway is triggered by particular members of the TNFR superfamily, such as lymphotoxin-beta (LT-beta) or BAFF. It involves NIK and IKK-alpha-mediated p100 phosphorylation and processing to p52, resulting in nuclear translocation of p52/RelB heterodimers.

Click Here to View the NF-Kappa B Signaling Pathway

 

 

  1. A77 1726

    A77 1726

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    A-2176 108605-62-5 5 mg
    $80.03
    25 mg
    $304.12
  2. Celastrol

    Celastrol

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    C-2262 34157-83-0 5 mg
    $64.03
    25 mg
    $245.43
  3. Leflunomide

    Leflunomide

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    L-2372 75706-12-6 10 mg
    $67.21
    50 mg
    $186.12
  4. ML130

    ML130

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    M-2383 799264-47-4 5 mg
    $90.70
    25 mg
    $362.81
  5. Nafamostat Mesylate

    Nafamostat Mesylate

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    F-1160 82956-11-4 10 mg
    $74.70
    50 mg
    $304.12
  6. Pam3Cys-Ser-(Lys)4, Trihydrochloride

    Pam3Cys-Ser-(Lys)4, Trihydrochloride

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    P-2378 112208-00-1/112208-04-5 100 ug
    $131.26
    2mg
    $367.07
  7. PDTC

    PDTC

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    P-2391 5108-96-3 100 mg
    $80.03
  8. Rocaglamide

    Rocaglamide

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    R-2420 84573-16-0 100 ug
    $368.15