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PI3 K/Akt/mTOR Signaling

The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in apoptosis and hence cancer (e.g.breast cancer and glioblastoma)The phosphatidylinositol 3-kinases (PI3Ks) are a family of lipid kinases whose primary biochemical function is to phosphorylate the 3-hydroxyl group of phosphoinositides PI3K activation activates AKT. AMP-activated protein kinase (AMPK) was initially identified as a serine/threonine kinase that negatively regulates several key enzymes of the lipid anabolism. AMPK is regarded as the major energy-sensing kinase that activates a whole variety of catabolic processes in multicellular organisms such as glucose uptake and metabolism, while simultaneously inhibiting several anabolic pathways, such as lipid, protein, carbohydrate biosynthesis and mTOR.

The proline-rich Akt substrate of 40 kDa (PRAS40) acts at the intersection of the Akt- and mammalian target of rapamycin (mTOR)-mediated signaling pathways. The protein kinase mTOR is the catalytic subunit of two distinct signaling complexes, mTOR complex 1 (mTORC1) and mTORC2, that link energy and nutrients to the regulation of cellular growth and energy metabolism. Alterations in Akt and mTOR activity have been linked to the progression of multiple diseases such as cancer and type 2 diabetes.

 

 Click Here to View the mTOR Signaling Pathway

  1. Anisomycin | CAS 22862-76-6 | Anti-fungal antibiotic | AG Scientific

    Anisomycin

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    A-1049 22862-76-6 10 mg
    $42.70
    50 mg
    $109.91
    100 mg
    $181.42
    500 mg
    $651.42
  2. BEZ235

    BEZ235

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    B-2199 915019-65-7 5 mg
    $133.39
    25 mg
    $314.79
  3. DiscoveryPak PI 3-Kinase Inhibitor Set

    DiscoveryPak PI 3-Kinase Inhibitor Set

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    D-2292 5 inhibitors
    $464.18
  4. GDC-0941

    GDC-0941

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    G-2335 957054-30-7 1 mg
    $170.61
    5 mg
    $584.21
  5. IC87114

    IC87114

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    I-2356 371242-69-2 1 mg
    $208.08
  6. Ins(3,4,5,6)P4

    Ins(3,4,5,6)P4

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    P-1111 100 ug
    $184.87
    500 ug
    $470.58
  7. KU-55933

    KU-55933

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    A-2189 587871-26-9 5 mg
    $176.07
  8. L-myoIns(1,4,5)P3.6K

    L-myoIns(1,4,5)P3.6K

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    I-1038 129828-71-3 1 mg
    $117.65
  9. LY294002 EZSolution™

    LY294002 EZSolution™

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    E-2312 154447-36-6 5 mg
    $85.37
  10. Neomycin.Sulfate | CAS 1405-10-3 | Antibiotic inhibits translation. An aminoglycoside antibiotic that inhibits translation by binding to the small subunit of prokaryotic ribosomes.

    Neomycin.Sulfate

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    N-1053 1405-10-3 25 g
    $18.14
    100 g
    $44.81
  11. PathwayReady PI3-K/Akt/mTOR Signaling Inhibitor Panel

    PathwayReady PI3-K/Akt/mTOR Signaling Inhibitor Panel

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    P-2384 11 inhibitors
    $997.73
  12. Phosphatidylinositol 3-Kinase SH3 Domain Binding Peptide

    Phosphatidylinositol 3-Kinase SH3 Domain Binding Peptide

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    P-1143 1 mg
    $93.91
  13. PI diC8

    PI diC8

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    P-1555 500 ug
    $229.42
    1 mg
    $432.17
  14. PI(3)diC16

    PI(3)diC16

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    P-1557 500 ug
    $229.42
    1 mg
    $432.17
  15. PI(4)P, di C8

    PI(4)P, di C8

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    P-1135 100 ug
    $96.04
    500 ug
    $288.11
  16. PI(4,5)P2, di C16

    PI(4,5)P2, di C16

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    P-1117 100 ug
    $64.03
    500 ug
    $224.09
  17. PI(4,5)P2,di C8

    PI(4,5)P2,di C8

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    P-1115 100 ug
    $74.70
    500 ug
    $224.09
  18. PI(5), di C16

    PI(5), di C16

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    P-1141 100 ug
    $64.03
    500 ug
    $224.09
  19. PI-103

    PI-103

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    P-2394 371935-74-9 1 mg
    $96.04
    5 mg
    $346.80
  20. PI3-K gamma Inhibitor, AS-605240

    PI3-K gamma Inhibitor, AS-605240

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    P-2395 648450-29-7 1 mg
    $69.36
    5 mg
    $261.44
  21. TGX-221

    TGX-221

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    T-2460 663619-89-4 1 mg
    $90.70
    5 mg
    $346.80
  22. Umirolimus

    Umirolimus

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    U-2581 851536-75-9 1 mg
    $109.91
    5 mg
    $385.22
  23. Wortmannin

    Wortmannin

    PRODUCT # CAS # SIZE PRICE QUANTITY BUY NOW
    W-1022 19545-26-7 1 mg
    $53.35
    5 mg
    $160.06
    25 mg
    $624.25