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Product Description
Cell permeable necrosis inhibitor with antioxidant activity. It localizes mostly in mitochondria. Selectively blocks oxidative stress-induced necrotic death (0.1μM Necrosis Inhibitor 5, prevented ˜50% cell death in H9C2 cells exposed to 400μM t-BuOOH for 2 hours LDH assay used).
Does not protect against staurosporine or Etoposide-induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stress in vitro, as well as, CCL4- induced acute liver and chronic liver fibrosis in rodent models.
in vitro Cell-based assays: Cold Stress, Hypoxia, Oxidative Stress.
in vivo Necrosis Animal Models for Liver disease: DILI (Acetaminophen, CCL4), CCL4 induced Liver Fibrosis/Cirrhosis.
Ischemia & Reperfusion Injury: Stroke, Myocardial Infarction, Acute Pancreatitis & Acute Tubular Necrosis.
Cell Media: Cell Therapy, CHO Growth.
Lit. Ref.: H.J. Kim, et al.; Arch. Pharm Res, 33, 1813 (2010).
Does not protect against staurosporine or Etoposide-induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stress in vitro, as well as, CCL4- induced acute liver and chronic liver fibrosis in rodent models.
in vitro Cell-based assays: Cold Stress, Hypoxia, Oxidative Stress.
in vivo Necrosis Animal Models for Liver disease: DILI (Acetaminophen, CCL4), CCL4 induced Liver Fibrosis/Cirrhosis.
Ischemia & Reperfusion Injury: Stroke, Myocardial Infarction, Acute Pancreatitis & Acute Tubular Necrosis.
Cell Media: Cell Therapy, CHO Growth.
Lit. Ref.: H.J. Kim, et al.; Arch. Pharm Res, 33, 1813 (2010).
Additional Information
| Product Number | N-1223 |
| Chemical Name | [[5-(1,1-Dioxo-thiomorpholin-4-ylmethyl)-2-phenyl-1H-indol-7-yl]-(tetrahydro-pyran-4-ylmethyl)-amine |
| Chemical Formula | C25H31NO3S.2CH4O3S |
| Alternative Name | Necrox-5 |
| Appearance | Gray Powder |
| Molecular Weight | 645.83 |
| Purity | ≥96% |
| Solubility | Soluble in DMSO (>10mg/ml) or distilled water (>10mg/ml) |
| Storage Temp | +4°C |
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All products sold by A.G. Scientific are strictly for Laboratory, Preclinical Research, or Bioprocessing purposes only. They are not intended for Human Drug, Food Additive, Clinical or Household use.
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