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![Necrostatin-5, necrosis cell death pathway. | Necroptosis pathway inhibitor, inhibits RIP1 Kinase indirectly. Neurostatin-5 CAS [337349-54-9]| Novel, apoptosis, necrosis & necroptosis regulate pathway reagents from A.G.Scientific.](http://www.agscientific.com/media/catalog/product/cache/1/thumbnail/56x/5e06319eda06f020e43594a9c230972d/f/i/file_3_12.jpg "Necrostatin-5, necrosis cell death pathway. | Necroptosis pathway inhibitor, inhibits RIP1 Kinase indirectly. Neurostatin-5 CAS [337349-54-9]| Novel, apoptosis, necrosis & necroptosis regulate pathway reagents from A.G.Scientific.")
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Product Description
Inhibits non-apoptotic cell death pathway by inhibition of the death domain receptor-associated adaptor kinase RIP1. Three distinct mechanisms appear to be involved in necroptosis, the alternative active cell death pathway: T-loop dependent inhibition by necrostatin-1; partially T-loop independent inhibition by necrostatin-3 and indirect inhibition of RIP1 by necrostatin-5
A. Degterev, et al.; Nat. Chem. Biol. 4, 313 (2008).
Additional Information
| Product Number | N-1229 |
| CAS # | 337349-54-9 |
| Chemical Name | 3-p-MEthoxyphenyl-5,6-tetramethylenothieno[2,3-d] pyrimidin-4-one-2-mercaptoethylcyanide |
| Chemical Formula | C19H17N3O2S2 |
| Alternative Name | Nec-5 |
| Appearance | White to off-white solid |
| Molecular Weight | 383.5 |
| Purity | ≥98% (NMR) |
| Solubility | Soluble in DMSO (>10mg/ml) |
| Storage Temp | -20°C |
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![Necrostatin-5 structure| Necroptosis pathway inhibitor, inhibits RIP1 Kinase indirectly. Neurostatin-5 CAS [337349-54-9]| Novel, apoptosis, necrosis & necroptosis regulate pathway reagents from A.G.Scientific](http://www.agscientific.com/media/catalog/product/cache/1/image/5e06319eda06f020e43594a9c230972d/placeholder/default/iso9001_lg_1.gif "Necrostatin-5 structure| Necroptosis pathway inhibitor, inhibits RIP1 Kinase indirectly. Neurostatin-5 CAS [337349-54-9]| Novel, apoptosis, necrosis & necroptosis regulate pathway reagents from A.G.Scientific")
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