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Inhibits non-apoptotic cell death pathway by inhibition of the death domain receptor-associated adaptor kinase RIP1. Three distinct mechanisms appear to be involved in necroptosis, the alternative active cell death pathway: T-loop dependent inhibition by necrostatin-1; partially T-loop independent inhibition by necrostatin-3 and indirect inhibition of RIP1 by necrostatin-5
A. Degterev, et al.; Nat. Chem. Biol. 4, 313 (2008).
|Chemical Name||3-p-MEthoxyphenyl-5,6-tetramethylenothieno[2,3-d] pyrimidin-4-one-2-mercaptoethylcyanide|
|Appearance||White to off-white solid|
|Solubility||Soluble in DMSO (>10mg/ml)|
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