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Neomycin.Sulfate | CAS 1405-10-3 | Antibiotic inhibits translation. An aminoglycoside antibiotic that inhibits translation by binding to the small subunit of prokaryotic ribosomes.

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Neomycin.Sulfate

CAS: 1405-10-3 Formula: C23H46N6O13.3H2SO4 MW: 908.9 Appearance: White or yellowish powder
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N-1053 25 g
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An aminoglycoside antibiotic that inhibits translation by binding to the small subunit of prokaryotic ribosomes. Also has high binding affinity to phosphatidylinositol 4,5-bisphosphate (PIP2).

We have demonstrated that neomycin was effective as secondary prophylaxis for irinotecan-induced diarrhea in three patients, and may have contributed to the prevention of diarrhea in a further two patients.1Neomycin as secondary prophylaxis for irinotecan-induced diarrhea, A. Schmittel, K. Jahnke, E., et al, Aug 2004; 15: 1296.


Neomycin Restores the Insulin-stimulated Glucose Transport Inhibited by the PI3K Inhibitor Wortmannin.2Neomycin Prevents the Wortmannin Inhibition of Insulin-stimulated Glut4 Translocation and Glucose Transport in 3T3-L1 Adipocytes, Declan J. James, Christine Salaün, et al, May 2004; 279: 20567 - 20570.

Additional Information

Product # N-1053
CAS # 1405-10-3
Formula C23H46N6O13.3H2SO4
MW 908.9
Appearance White or yellowish powder
Solubility Readily Soluble in Water and Dilute Aqueous Base
Storage Temp Room Temp, Warning! Toxic. May be Carcinogenic. May be Teratogenic. Protect from Light. Protect from Moisture.

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Merck Index 13.6482.2001

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GHS Pictograms
RTECS QP4375000

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Certificate of Analysis 1 N-1053_N-1053,_A8397.pdf
Certificate of Analysis 2 N-1053, B1809 r01.pdf

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Neomycin.Sulfate

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