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Image courtesy of Public Library of Science publication.  
Cytoplasmic Accumulation and Aggregation of TDP-43 upon Proteasome Inhibition in Cultured Neurons from researchers at Laboratory for Translational Neurodegeneration, Brain & Mind Research Institute, University of Sydney, Sydney, Australia, Alzheimer's and Parkinson's Disease Laboratory, Brain & Mind Research Institute, University of Sydney, Sydney, Australia, Disciplines of Medicine and Pathology, University of Sydney, Sydney, Australia. Proteasome inhibition by lactacystin treatment induces cytoplasmic accumulation of TDP-43 (TAR DNA-binding protein 43) in primary neurons under various stress conditions.

Apoptosis is the process of programmed cell death. It is a normal and necessary phenomenon for many biological developmental processes, allowing cells to differentiate from each other and to form proper connections. It is also a critical phenomenon in aging and in healthy cell turnover; the healthy adult human body sheds tens of billions of cells each day in order to maintain homeostasis. Excessive or faulty apoptosis is associated with many human disorders such as neurodegenerative and auto-immune diseases and the proliferation of cancers. The machinery and signaling pathways that control cell life and death are key areas in human therapeutic research. AG Scientific is proud to offer products that can identify, inhibit or promote apoptosis.


AG Scientific delivers quality assured reagents directly to scientists, from small-scale to bulk orders. Our leadership in bulk supply allows us to provide custom product packaging and create multiple product forms. We offer “just in time” delivery, private labeling, and custom formulations for specific research needs.

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  • Product Number: B-1285

    The inactive enantiomer. Also useful as a negative control for the more active enantiomer (-)-Blebbistatin, B-1287. New product inquire for

  • Product Number: B-1287

    The active enantiomer that counts for the inhibitory activity toward ATPase (IC₅₀ ~2 µM) and myosin II-dependent cellular processes. Ne

  • Product Number: A-1049

    Anisomycin is a pyrrolidine antibiotic, that acts as an anti-fungal

  • Product Number: B-1225

    Source: Rabbit. Immunogen: Synthetic peptide corresponding to aa 201-216 of human Bcl-X. Specificity: Recognizes human, mouse, rat Bcl-XL (s

  • Product Number: A-1700

    Source: Islolated from marine mussel. Activator of JNK (c-Jun-N-terminal kinase). Cellular growth inhibitor and inducer of cytoskeletal alte

  • Product Number: C-1099

    Inhibitor of Fas-mediated apoptosis. Cell permeable and irreversible caspase-1 inhibitor. Also inhibits caspase-4.

  • Product Number: C-1415

    Based on detection of AFC after cleavage from the labeled substrate IETD-AFC. IETD-AFC emits blue light, upon cleavage free AFT will emit ye

  • Product Number: C-1467

    Produced in E Coli, untagged mouse CDNF (aa 27-187). Conserved Dopamine Neurotropic Factor, CDNF, is a new protein with beneficial effects

  • Product Number: C-1553

    Potent, cell permeable and selective inhibitor of CDK1 (IC₅₀=340nM) the cell cycle -regulating kinase Cdc28p (IC₅₀=7µM) and the rel

  • Product Number: B-1229

    Immunogen: Full length human recombinant BIF-1. Specificity: Recognizes human BIF-1. Isotype: mouse IgG. Application: WB.

  • Product Number: D-1291

    Immunogen: Mouse recombinant DLC1. Specificity: Recognizes human and mouse DLC1. Dese not cross-react with DLC2. Isotype: Rat IgM. Applicati

  • Product Number: N-1215


  • Product Number: O-1072

    The cysteine-rich region of human Osteoprotegerin (aa 22-202) is fused to the Fc portion of human IgG1. rhOPG: Fc inhibits solubl

  • Product Number: P-1293

    Source: Rabbit. Immunogen: Synthetic peptide corresponding to aa 1026-1044 (S1026WKTKVNWLAHNVSKDNRQ1044) of the C-terminal domain of human p

  • Product Number: S-2128

    A convenient set of three small molecules useful for promoting the survival of embryonic stem cells (ESCs). The three products are: 1 mg

  • Product Number: S-2096

    A potent inhibitor of Src-family protein tyrosine kinases. Inquire for more details, pricing & lead time.

  • Product Number: T-1038

    Kit contains 50 μg of rmsTNF-α plus 2x50ug of an enhancer. In the presence of the enhancer, rmsTNF-α recognizes human, mouse and rat TNF-

  • Product Number: T-1080

    The Set contains 50 μg each of rhTRAIL-Rl, rhTRAIL-R2, rhTRAIL-R3: and rhTRAIL-R4:Fc

  • Product Number: T-1066

    Produced in E. coli. The extracellular domain of human TRAIL is fused at the N-terminus to a FLAG-tag and an 8 aa linker peptide.

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    Selective inhibitor of anandamide uptake that does not activate vanilloid receptor VR1.