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Ionophores
Image courtesy of Public Library of Science publication Bcl-xL Blocks a Mitochondrial Inner Membrane Channel and Prevents Ca2+ Overload-Mediated Cell Death from researchers at Unidad Asociada Neurodeath, Universidad de Castilla-La Mancha, Albacete, Spain, Laboratorio de Inmunobiología Molecular, Hospital General Universitario Gregorio Marañón, Madrid, Spain, Centro de Investigación Biomédica En Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain. SH-SY5Y/Neo and SH-SY5Y/Bcl-xL cells treated with ionomycin and visualized through calcein fluorescence.
AG Scientific: A leader in ionophores
Ionophores are used to increase the permeability of biological membranes and facilitate transfer of molecules into and out of cells. Ionophores unique molecular properties allow them to be used in a variety of functions. AG Scientific can supply a variety of ion selective electrodes for your needs, we have had particular success with the following:
- Valinomycin is used in ion selective electrodes to diagnostically measure potassium (K+) concentrations.
- Ionomycin is selective for calcium ions (Ca2+); it increases membrane permeability to calcium thus increasing calcium concentration in the cell.
- Calcimycin also known as (A23187) is a calcium ionophore with antibiotic properties that kill gram positive bacteria and fungi. This ionophore increases intracellular Ca2+ concentrations, and can either initiate or prevent apoptosis in different cell types.
- Nonactin selectively forms complexes with ammonium, thallium, and potassium cations to carry them across lipid membranes.
AG Scientific delivers quality assured reagents directly to scientists, from small-scale to bulk orders. Our leadership in bulk supply allows us to provide custom product packaging and create multiple product forms. We offer “just in time” delivery, private labeling, and custom formulations for specific research needs.
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