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Product Description
A STAT3 signaling pathway inhibitor. Niclosamide potently inhibits the activation and transcriptional function of STAT3 and induces cell growth inhibition, apoptosis, and cell cycle arrest of cancer cells with constitutively active STAT3.
Also reversibly inhibits mTORC1 signaling and stimulates autophagy in vitro; displays antineoplastic effects in acute myelogenous leukemia (AML) stem cells.
Also reversibly inhibits mTORC1 signaling and stimulates autophagy in vitro; displays antineoplastic effects in acute myelogenous leukemia (AML) stem cells.
Additional Information
| Product Number | N-1219 |
| CAS # | 50-65-7 |
| Chemical Name | 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide |
| Chemical Formula | C₁₃H₈Cl₂N₂O₄ |
| Appearance | Off-white to pale yellow solid |
| Molecular Weight | 327.12 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (10 mM) or Ethanol (25 mM) |
| Storage Temp | -20°C |
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