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Nonactin  CAS 6833-84-7  NH4+ & K+ ionophore | AG Scientific Potassium ionophore

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Nonactin, Macrotetrolide antibiotic

CAS: 6833-84-7 Formula: C40H64O12 MW: 736.9 Appearance: White Needles Purity: 99%
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N-1155 10 mg
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Nonactin is a cyclic ionophore commonly produced by several species of Streptomyces which selectively binds K+ and NH4+. Nonactin has been reported to inhibit the processing of cytoplasmic precursor proteinsdestined for the mitochondria. Nonactin is an uncoupler of oxidative phosphorylation and induces ATP hydrolysis at a concentration of  1x10-7 M.

Nonactin has been shown to inhibit the production and gene transcription of IL-5 but not of IL-2 or IL-4. Nonactin has also been used as an ammonium ionophore for ammonium ion determination in a potentiometric electrode for biosensor construction as well as in a fluorescent immuno assay to detect K+ ions in pharmaceutical samples.

In the presence of Thallus acetate, Nonactin has further stimulated the swelling of rat liver mitochondria than thallus acetate alone. It also has inhibited the effects on P170 glycoprotein-mediated efflux of chemotherapeutic agents in MDR cancer cells.

 

Additional Information

Product # N-1155
CAS # 6833-84-7
Chemical Name (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-2,5,11,14,20,23,29,32-OCTAMETHYL-4,13,22,31,37,38,39,40-OCTAOXAPENTACYCLO[32.2.1.17,10.116,19.125,28]TETRACONTANE-3,12,21,30-TETRONE
Formula C40H64O12
MW 736.9
Appearance White Needles
Purity 99%
Solubility DMSO (~25 mg/ml)
Boiling Point 890.6±65.0 °C at 760 mmHg
Storage Temp +4°C
Use Macrotetrolide antibiotic which acts as a monovalent cation ionophore and demonstrates high selectivity for ammonium and potassium

Additional Information

MDL Number MFCD03267283
ChemACX X1009767-7
InChI InChI=1S/C40H64O12/c1-21-17-29-9-13-34(49-29)26(6)38(42)46-23(3)19-31-11-15-36(51-31)28(8)40(44)48-24(4)20-32-12-16-35(52-32)27(7)39(43)47-22(2)18-30-10-14-33(50-30)25(5)37(41)45-21/h21-36H,9-20H2,1-8H3/t21-,22+,23+,24-,25-,26+,27+,28-,29-,30+,31+,32-,33-,34+,35+,36-
SMILES C[C@@H]1C[C@H]2CC[C@H](O2)[C@@H](C(=O)O[C@H](C[C@@H]3CC[C@@H](O3)[C@H](C(=O)O[C@@H](C[C@H]4CC[C@H](O4)[C@@H](C(=O)O[C@H](C[C@@H]5CC[C@@H](O5)[C@H](C(=O)O1)C)C)C)C)C)C)C

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GHS Pictograms
RTECS RH1685000
Handling Store in Tightly Sealed Vial Protect from moisture.

Additional Information

Certificate of Analysis 1 N-1155, F1211B.pdf
Certificate of Analysis 2 N-1155, F1211A.pdf
Certificate of Analysis 3 N-1155, F1211.pdf

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Nonactin, Macrotetrolide antibiotic

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