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Pepstatin A, Inhibitor of aspartic proteases

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Pepstatin A, Inhibitor of aspartic proteases

CAS: 26305-03-3 Formula: C34H63N5O9 MW: 685.9 Appearance: White Solid Purity: 98%
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P-1519 5 mg
$34.10
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25 mg
$98.00
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Pepstatin A is a competitive, reversible aspartic protease inhibitor and inhibits proteases such as pepsin, chymosin, renin, HIV proteases, and cathepsins D and E. It is highly selective and is often used in a mixture with other enzyme inhibitors. In vitro studies have shown pepstatin A is the only aspartic acid inhibitor that exhibits inhibitory effects on HIV proteases.

Pepstatin A may also suppress differentiation of osteoclasts by inhibiting phosphorylation of MAP kinase and inhibiting NFATc1 expression. Pepstatin A application in cold inducible RNA-binding protein (CIRP) via CRISPR-Cas9 system1. Pepstatin A inhibits lysosomal proteases directly2.

1.) http://nar.oxfordjournals.org/content/44/2/761.full.pdf+html

2.) http://www.pnas.org/content/112/31/E4281.full.pdf

Additional Information

Synonyms Isovaleryl-L-Val-L-Val-AHMHA-L-Ala-AHMHA (AHMHA=(3S, 4S)-4-Amino-3-hydroxy-6-methyl-heptanoic acid)
Product # P-1519
CAS # 26305-03-3
Chemical Name Isovaleryl-L-Val-L-Val-AHMHA-L-Ala-AHMHA (AHMHA=(3S, 4S)-4-Amino-3-hydroxy-6-methyl-heptanoic acid)
Formula C34H63N5O9
MW 685.9
Appearance White Solid
Purity 98%
Solubility DMSO (5 mg/ml) or Methanol (1 mg/ml)
Boiling Point 997.6±65.0 °C at 760 mmHg
Storage Temp -20°C
Use Pepstatin A is a potent reversible inhibitor of aspartic proteases.

Additional Information

MDL Number MFCD00060740
ChemACX X1036275-1
InChI InChI=1S/C34H63N5O9/c1-17(2)12-23(37-33(47)31(21(9)10)39-34(48)30(20(7)8)38-27(42)14-19(5)6)25(40)15-28(43)35-22(11)32(46)36-24(13-18(3)4)26(41)16-29(44)45/h17-26,30-31,40-41H,12-16H2,1-11H3,(H,35,43)(H,36,46)(H,37,47)(H,38,42)(H,39,48)(H,44,45)/t22-,23-,24-,25-,26-,30-,31-/m0/s1
SMILES C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)O)O)NC(=O)C[C@@H]([C@H](CC(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)CC(C)C)O
Peptide Sequence ISOVALERYL-VAL-VAL-STA-ALA-STA-OH

Additional Information

GHS Pictograms
RTECS SC6155000
Handling Protect from Light

Additional Information

msds 1 P-1519, SDS.pdf
Certificate of Analysis 1 P-1519, F1259B.pdf
Certificate of Analysis 2 P-1519, F1259A.pdf
Certificate of Analysis 3 P-1519, F1259.pdf

Additional Information

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Pepstatin A, Inhibitor of aspartic proteases

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