PHOSPHATASE INHIBITOR COCKTAILS

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PHOSPHATASE INHIBITOR COCKTAILS

A phosphatase is an enzyme that removes a phosphate group from its substrate by hydrolysing phosphoric acid monoesters into a phosphate ion and a molecule with a free hydroxyl group (see dephosphorylation). This action is directly opposite to that of phosphorylases and kinases, which attach phosphate groups to their substrates by using energetic molecules like ATP. A common phosphatase in many organisms is alkaline phosphatase.

Protein phosphorylation is the most common and important form of reversible protein posttranslational modification (PTM), with up to 30% of all proteins being phosphorylated at any given time. Protein kinases (PKs) are the effectors of phosphorylation and catalyse the transfer of a γ-phosphate from ATP to specific amino acids on proteins. Several hundred PKs exist in mammals and are classified into distinct super-families. Proteins are phosphorylated predominantly on Ser, Thr and Tyr residues, which account for 86, 12 and 2% respectively of the phosphoproteome, at least in mammals.

In contrast, protein phosphatases (PPs) are the primary effectors of dephosphorylation and can be grouped into three main classes based on sequence, structure and catalytic function. The largest class of PPs is the phosphoprotein phosphatase (PPP) family comprising PP1, PP2A, PP2B, PP4, PP5, PP6 and PP7, and the protein phosphatase Mg2+- or Mn2+-dependent (PPM) family, composed primarily of PP2C. The protein Tyr phosphatase (PTP) super-family forms the second group, and the aspartate-based protein phosphatases the third.

FREE REVIEW ARTICLES

Phosphatase-1 inhibitor-1 in physiological and pathological β-adrenoceptor signalling, Katrin Wittköpper, Dobromir Dobrev, et al. Phosphatase-1 inhibitor-1 in physiological and pathological β-adrenoceptor signalling. Cardiovasc Res, 2011; 91: 392 - 401.

Regulation of the Cell Cycle by Protein Phosphatase 2A in Saccharomyces cerevisiae, Yu Jiang. Regulation of the Cell Cycle by Protein Phosphatase 2A in Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev, 2006; 70: 440 - 449.

Phosphatase Inhibition Delays Translational Recovery, R. Luke Wiseman and Jeffery W. Kelly. Phosphatase Inhibition Delays Translational Recovery. Science, 2011; 332: 44 - 45.

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Product Number	E-2030
CAS #	CAS[66701-25-5]
Chemical Name	trans-Epoxysucciny-L-leucyl-amido(4-guanidino) butane; (L-3-trans-Carboxyoxiran-2-Carbonyl)-L-Leucyl-Admat
Chemical Formula	C₁₅H₂₇N₅O₅
Alternative Name	E64
Appearance	White Solid
Molecular Weight	M.W. 357.4
Purity	Purity:>99%
Solubility	DMSO (25mg/ml) and H20 (20mg/ml)
Storage Temp	-20°C

MSDS Documentation: E-2030, E-64, MSDS COA Documentation: E-2030, B1549 E-2030, B1682 E-2030, C1175 E-2030, C1306 E-64 Product Number: E-2030
Price	Price	Qty	Add to Cart
1x5 mg	$45.00
1x25 mg	$180.00

Product Number	I-1332
CAS #	331001-62-8
Chemical Name	2-[(4-Acetylphenyl)azo]-2-(3,4-dihydro-3, 3-dimethyl-1 (2H)-isoquinolinylidene)-acetamide
Chemical Formula	C₂₁H₂₂N₄O₂
Appearance	Orange Solid
Molecular Weight	362.42
Purity	≥95% by HPLC
Solubility	DMSO
Storage Temp	Keep cool and dry. Store at +4°C

IQ-1 Product Number: I-1332
Price	Price	Qty	Add to Cart
1x1 mg	$135.00

Product Number	L-1165
CAS #	CAS [103476-89-7]
Chemical Name	Ac-Leu-Leu-Arginal
Chemical Formula	C₂₀H₃₈N₆O₄.0.5 H₂SO₄
Alternative Name	Ac-Leu-Leu-Arginal, Leupeptin
Appearance	White Solid
Molecular Weight	M.W. 475.6
Purity	Purity: Three tautomeric isomers in solution
Solubility	Soluble in H20 (50mg/ml). Effective concentration 10-100uM
Storage Temp	-20°C

MSDS Documentation: L-1165, MSDS.pdf COA Documentation: L-1165, C1165E L-1165, D1017A L-1165, C1165D L-1165, D1017 Leupeptin, Hemisulfate Product Number: L-1165
Price	Price	Qty	Add to Cart
1x5 mg	$22.00
1x25 mg	$93.50
1x100 mg	$330.00

Product Number	O-1030
CAS #	CAS [209266-80-8]
Chemical Name	9,10-Deepithio-9,10-didehydroacanthifolicin, Halochondrine A. Na, Halochondrine A sodium salt
Chemical Formula	C₄₄H₆₇O₁₃.Na
Appearance	White Solid
Melting Point	MP: 164-166°C
Merck Index	Merck Index: 16.6891.2001
Molecular Weight	M.W. 828.00
Purity	Purity: >98%
Solubility	Soluble in DMSO, Ethanol, and Water.
Storage Temp	-20°C

COA Documentation: O-1030, B1011 O-1030, B1229 O-1030, C1342 O-1030, C1366 Okadaic Acid Sodium Salt, Prorocentrum concavum Product Number: O-1030
Price	Price	Qty	Add to Cart
1x25 μg	$45.00
1x50 ug	$65.00
1x100 μg	$103.00

Product Number	O-1024
CAS #	CAS [78111-17-8]
Chemical Name	9,10-Deepithio-9,10-didehydroacanthifolicin, Halochondrine A
Chemical Formula	C₄₄H₆₈O₁₃
Appearance	White Crystalline Solid
Melting Point	MP: 164-166°C
Merck Index	Merck Index: 13.6891.2001
Molecular Weight	M.W. 805.0
Purity	Purity:≥98% (HPLC)
Solubility	Soluble in DMSO, 100% ethanol or methanol (1mg/ml).
Storage Temp	-20°C

COA Documentation: O-1024, A9183 O-1024, B1185 Okadaic acid, Prorocentrum concavum, High Purity Product Number: O-1024
Price	Price	Qty	Add to Cart
1x50 μg	$70.00
1x100 μg	$103.00
1x1 mg	$830.00

Product Number	O-1026
CAS #	CAS [155716-06-6]
Chemical Name	9,10-Deepithio-9,10-didehydroacanthifolicin . Na (high purity)
Chemical Formula	C₄₄H₆₈O₁₃.NH₃
Alternative Name	Halochondrine A . Ammonium salt (high purity)
Appearance	White to off-white solid
Melting Point	MP: 164-166°C
Molecular Weight	M.W. 822.0
Purity	Purity: ≥98% (HPLC)
Solubility	Soluble in (100%) ethanol, DMSO,methanol, acetone, ethyl acetate or destilled water.
Storage Temp	-20°C

COA Documentation: O-1026, A8731 O-1026, B1960 Okadaic acid.Ammonium Salt, Prorocentrum concavum Product Number: O-1026
Price	Price	Qty	Add to Cart
1x25 μg	$45.00
1x50 ug	$65.00
1x100 μg	$103.00

Product Number	O-1028
CAS #	CAS [155751-72-7]
Chemical Name	9,10-Deepithio-9,10-didehydroacanthifolicin . sodium salt (high purity)
Chemical Formula	C₄₄H₆₇O₁₃.K
Alternative Name	Halochondrine A . potassium salt (high purity)
Appearance	White Solid
Melting Point	MP: 164-166°C
Merck Index	Merck Index: 13.6891.2001
Molecular Weight	M.W. 844.1
Purity	Purity: >98%
Solubility	Soluble in DMSO, Ethanol, and Water.
Storage Temp	-20°C

COA Documentation: O-1028, C1047 O-1028, B1959 O-1028, C1238 O-1028, C1324 Okadaic acid.Potassium Salt, Prorocentrum concavum Product Number: O-1028
Price	Price	Qty	Add to Cart
1x25 ug	$45.00
1x50 ug	$70.00
1x100 ug	$103.00

Product Number	P-1517
Appearance	Clear colorless liquid. In 1ml DMSO.
Purity	Suitable for use as Phosphatase Inhibitor
Solubility	Recommended usage is 100-fold dilution
Storage Temp	-20°C

MSDS Documentation: P-1517, PHOSPHATASE INHIBITOR COCKTAIL I, MSDS COA Documentation: P-1517, B1912 P-1517, C1180 P-1517, D1030 Phosphatase Inhibitor Cocktail I Product Number: P-1517
Price	Price	Qty	Add to Cart
1x1 vial	$38.00

Product Number	P-1518
Appearance	White Lyophilized Solid
Solubility	Reconstitute each vial with 1 ml H2O to obtain a 1 ml stock solution. Recommended usage is a 100-fold dilution.
Storage Temp	-20°C

MSDS Documentation: P-1518, MSDS COA Documentation: P-1518, C1154 P-1518, C1181 P-1518, C1304 P-1518, C1346 Phosphatase Inhibitor Cocktail II Product Number: P-1518
Price	Price	Qty	Add to Cart
1x1 vial	$38.00

Product Number	P-1549
Appearance	White Lyophilized Solid.
Solubility	Soluble in water, aqueous buffers, or add directly to extraction media. Reconstitute each vial with 1 ml H2O to obtain a 1 ml stock solution.
Storage Temp	-20°C

COA Documentation: P-1549, B1915 P-1549, C1091 P-1549, C1234 Phosphatase Inhibitor Cocktail III Product Number: P-1549
Price	Price	Qty	Add to Cart
1x1 vial	$54.00

Product Number	P-1550
Appearance	Clear colorless liquid.
Purity	Suitable for use as Phosphatase Inhibitors
Solubility	Supplied as a liquid in 1 ml DMSO. Add to water, aqueous buffer or directly to extraction media.
Storage Temp	-20°C

COA Documentation: P-1550, B1904 P-1550, C1219 P-1550, C1253 P-1550, D1062 Phosphatase Inhibitor Cocktail IV Product Number: P-1550
Price	Price	Qty	Add to Cart
1x1 ml	$54.00

Product Number	P-1552
CAS #	n/a
Chemical Name	n/a
Chemical Formula	n/a
Appearance	Lyophilized solid
Melting Point	n/a
Merck Index	n/a
Molecular Weight	n/a
Purity	n/a
Solubility	Soluble in 1ml H₂O to obtain 1 ml stock solution.
Storage Temp	-20°C

COA Documentation: P-1552, B1353 PIA 1000X Protease Inhibitor A Product Number: P-1552
Price	Price	Qty	Add to Cart
1x1 vial each	$45.00

Product Number	P-1540
Appearance	White Solid
Purity	Suitable for use as Protease Inhibitor
Solubility	Reconstitute each vial with 1 ml H2O to obtain a 100X concentrated stock solution. Soluble in water, aqueous buffers, or add directly to extraction media. Dilute with 100ml solution to achieve 1X stock solution.
Storage Temp	-20°C

COA Documentation: P-1540, B1913 Protease Inhibitor Cocktail I, Animal Free Product Number: P-1540
Price	Price	Qty	Add to Cart
1x1 vial	$29.00

Product Number	P-1511
Appearance	White Lyophilized Solid
Solubility	Reconstitute each vial with 1ml DMSO and 4ml H20 to obtain a 5ml stock solution.
Storage Temp	-20°C

COA Documentation: P-1511, C1144 P-1511, C1242 P-1511, D1085 Protease Inhibitor Cocktail II Product Number: P-1511
Price	Price	Qty	Add to Cart
1x1 Vial	$38.00

Product Number	P-1512
Appearance	Liquid, in 1ml DMSO
Purity	suitable for use as Protease Inhibitors.
Storage Temp	-20°C

COA Documentation: P-1512, C1030 P-1512, C1226 P-1512, C1367 Protease Inhibitor Cocktail III Product Number: P-1512
Price	Price	Qty	Add to Cart
1x1 Vial	$38.00

Product Number	P-1514
Appearance	White Lyophilized Solid
Solubility	Reconstitute each vial with 1 ml H2O to obtain a 100X concentrated stock solution. Dilute with 100ml solution to achieve 1X stock solution.
Storage Temp	-20°C

COA Documentation: P-1514, B1911 P-1514, C1048 P-1514, C1236 P-1514, D1079 Protease Inhibitor Cocktail V, EDTA-Free Product Number: P-1514
Price	Price	Qty	Add to Cart
1x1 vial	$25.00

Product Number	P-1544
Appearance	White Lyophilized Solid.
Purity	Suitable for use as Protease Inhibitors.
Solubility	Soluble in water, aqueous buffers, or add directly to extraction media. Reconstitute each vial with 1 ml H2O to obtain a 100X concentrated stock solution. Dilute with 100ml solution to achieve 1X stock solution.
Storage Temp	-20°C

COA Documentation: P-1544, C1015 Protease Inhibitor Cocktail V, EDTA-Free, Animal-Free Product Number: P-1544
Price	Price	Qty	Add to Cart
1x1 vial	$38.00

Product Number	P-1515
Appearance	White Lyophilized Solid
Solubility	Reconstitute each vial with 100 ml H2O to obtain a 100 ml cocktail solution.
Storage Temp	-20°C

MSDS Documentation: P-1515, Protease Inhibitor Cocktail VI COA Documentation: P-1515, B1594 P-1515, C1354 P-1515, C1359 Protease Inhibitor Cocktail VI, (General Use) Product Number: P-1515
Price	Price	Qty	Add to Cart
1x1 vial	$31.00

Product Number	P-1547
Appearance	White Lyophilized Solid.
Purity	Suitable for use as Protease Inhibitor
Solubility	Soluble in DMSO, water, aqueous buffer, or add directly to extraction media.
Storage Temp	-20°C

COA Documentation: P-1547, DATA SHEET P-1547, C1216 Protease Inhibitor Cocktail VII, DMSO-Free (for His Tag Sequences) Product Number: P-1547
Price	Price	Qty	Add to Cart
1x1 vial	$59.00

Product Number	P-1548
Appearance	Clear Colorless Solution
Purity	Suitable for use as Protease Inhibitors.
Solubility	Supplied as a liquid in 1 ml DMSO. Add to water, aqueous buffer or directly to extraction media.
Storage Temp	-20°C

COA Documentation: P-1548, B1523 P-1548, C1312 Protease Inhibitor Cocktail VIII Product Number: P-1548
Price	Price	Qty	Add to Cart
1x1 ml	$54.00

Product Number	C-1606
Appearance	Lyophilized from 5% sucrose in 10 mM HEPES buffer, pH 7.0; 150 mM NaCl; protease inhibitors: 1 mM EDTA, 1 mM EGTA, 1 mM PMSF, 1 mM AEBSF, 5 μg/ml leupeptin, 1 mM benzamidine; phosphatase inhibitors: 50 μM orthovanadate, 100 μM sodium fluoride, 2.5 mM sodi
Solubility	Reconstitute in 500 μL H₂O. Aliquot and freeze unused material at -20ºC.
Storage Temp	-20°C

ProteomeStore™ Kidney, Cytosolic Proteins, Undenatured, Rat, Sprague Dawley Product Number: C-1606
Price	Price	Qty	Add to Cart
1x5 mg	$95.00

Product Number	C-1612
Appearance	Lyophilized from 5% sucrose in 10 mM HEPES buffer, pH 7.0; 150 mM NaCl; protease inhibitors: 1 mM EDTA, 1 mM EGTA, 1 mM PMSF, 1 mM AEBSF, 5 μg/ml leupeptin, 1 mM benzamidine; phosphatase inhibitors: 50 μM orthovanadate, 100 μM sodium fluoride, 2.5 mM sodi
Solubility	Reconstitute in 500 μL H₂O. Aliquot and freeze unused material at -20ºC.
Storage Temp	-20°C

ProteomeStore™ Lung, Cytosolic Proteins, Undenatured, Rat, Sprague Dawley Product Number: C-1612
Price	Price	Qty	Add to Cart
1x5 mg	$95.00

Product Number	C-1614
Appearance	Lyophilized from 5% sucrose in 10 mM HEPES buffer, pH 7.0; 150 mM NaCl; protease inhibitors: 1 mM EDTA, 1 mM EGTA, 1 mM PMSF, 1 mM AEBSF, 5 μg/ml leupeptin, 1 mM benzamidine; phosphatase inhibitors: 50 μM orthovanadate, 100 μM sodium fluoride, 2.5 mM sodi
Solubility	Reconstitute in 500 μL H₂O. Aliquot and freeze unused material at -20ºC.
Storage Temp	-20°C

ProteomeStore™ Spleen, Cytosolic Proteins, Undenatured, Rat, Sprague Dawley Product Number: C-1614
Price	Price	Qty	Add to Cart
1x5 mg	$95.00

Product Number	S-2140
CAS #	See under the individual product
Chemical Name	See under the individual product
Chemical Formula	See under the individual product
Alternative Name	StemBoost
Appearance	Liquid
Molecular Weight	See under the individual product
Purity	≥97% by HPLC
Solubility	N/A
Storage Temp	-20°C

Reprogramming Cocktail Set II (1000X), Sterile-Filtered Product Number: S-2140
Price	Price	Qty	Add to Cart
1x1 ml	$195.00
1x5 ml	$695.00
5x1 ml	$725.00

COA Documentation: P-1516, B1918 P-1516, B1733 P-1516, C1235 Serine Protease Inhibitor Cocktail I Product Number: P-1516
Price	Price	Qty	Add to Cart
1x1 vial	$59.00

StemBoostReprogramming Cocktail Set I (1000X), Sterile-Filtered Product Number: S-2142
Price	Price	Qty	Add to Cart
1x1 ml	$195.00
1x5 ml	$695.00
5x1 ml	$725.00

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PHOSPHATASE INHIBITOR COCKTAILS

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Product Number	P-1516
Appearance	White Lyophilized Solid
Solubility	Reconstitute each vial with 1 ml H2O to obtain a 100X concentrated stock solution.
Storage Temp	-20°C.

Product Number	S-2142
CAS #	See under the individual product
Chemical Name	See under the individual product
Chemical Formula	See under the individual product
Appearance	Liquid
Molecular Weight	See under the individual product
Purity	≥97% by HPLC
Solubility	N/A
Storage Temp	-20°C