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Purmorphamine

PURMORPHAMINE
Product Number: P-1633

        

Details

A cell-permeable purine compound that induces osteoblast differentiation in C3H10T1/2 multipotent mesenchymal progenitor cells (EC = 1 M) and in MC3T3-E1 lineage-committed preosteoblasts. Also shown to induce transdifferentiation in pre-adipocytes and myoblasts. Its effects are reported to be synergistic with bone morphogenetic protein-4 (BMP-4). Reported to induce osteogenesis by activation of the Hedgehog signaling pathway.

Additional Information

Alternate Name/Synonyms 2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine
Chemical name (IUPAC) 9-CYCLOHEXYL-N-[4-(4-MORPHOLINYL)PHENYL]-2-(1-NAPHTHALENYLOXY)-9H-PURIN-6-AMINE
Molecular Formula C31H32N6O2
MP/BOILING POINT 790.3±70.0 °C at 760 mmHg
CHEMACX X1600485-6
Handling Protect from Light Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Soluble DMSO (200 mg/ml)
INDICATION Osteogenesis in bone tissue
MDL NUMBER MFCD09037557
INCHI InChI=1S/C31H32N6O2/c1-2-9-25(10-3-1)37-21-32-28-29(33-23-13-15-24(16-14-23)36-17-19-38-20-18-36)34-31(35-30(28)37)39-27-12-6-8-22-7-4-5-11-26(22)27/h4-8,11-16,21,25H,1-3,9-10,17-20H2,(H,33,34,35)
SMILES c1ccc2c(c1)cccc2Oc3nc(c4c(n3)n(cn4)C5CCCCC5)Nc6ccc(cc6)N7CCOCC7
THERAPEUTIC AREA Musculoskeletal Disorders
USE An activator of the hedgehog (Hh) signaling pathway induce osteogenesis in bone tissue
Product Number P-1633
Chemical Name 2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine
Chemical Formula C31H32N6O2
Alternative Name Shh Signaling Agonist
Appearance Beige Solid Packaged under inert gas
Handling Protect from Light Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Molecular Weight 520.6
Purity 98% by HPLC
Solubility DMSO (200 mg/ml)
Storage Temp +4°C

Purmorphamine

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