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Puromycin is an aminoglysidic antibiotic derived from the Streptomyces alboniger bacterium. Puromycin is a protein inhibitor by inhibiting translation.
Puromycin's main function is used in cell biology as a selective antibiotic agent in cell culture systems. It is also ued for selecting mammalian cell lines, which have been transformed by vectors that express puromycin-N-acetyl-transferase (PAC). It is toxic to procaryotic & eukaryotic cells.
Attached is a published reference from researchers who have used our product.
- The mTORC1 signaling repressors REDD1/2 are rapidly induced and activation of p70S6K1 by leucine is defective in skeletal muscle of an immobilized rat hindlimb, Andrew R. Kelleher, et al, Am J Physiol Endocrinol Metab, Jan 2013; 304: E229 - E236.
- CELL BIOLOGY: CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53, Dingding Shi, et al, PNAS, Sep 2009; 106: 16275 - 16280.
- NEOPLASIA: High TCL1 expression and intact T-cell receptor signaling define a hyperproliferative subset of T-cell prolymphocytic leukemia, Marco Herling, et al, Blood, Jan 2008; 111: 328 - 337.
- CELL, TUMOR, AND STEM CELL BIOLOGY: Inhibition of Gastric Cancer Invasion and Metastasis by PLA2G2A, a Novel β-Catenin/TCF Target Gene, Kumaresan Ganesan, Cancer Res., Jun 2008; 68: 4277 - 4286.
- The Aryl Hydrocarbon Receptor Binds to E2F1 and Inhibits E2F1-induced Apoptosis, Jennifer L. Marlowe, et al, Mol. Biol. Cell, Aug 2008; 19: 3263 - 3271.
|CAS #||CAS [58-58-2]|
|Chemical Name||(S) 3'-[[2-Amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine,3'-(a-Amino-p-methoxy-hydocinnamamido)-3'-dexoy-N,N-dimethyladenosine.2HCl|
|Alternative Name||Puromycin | CAS [58-58-2]| Gene Selection Antibiotic||
|Appearance||White to Off-White Powder|
|Merck Index||Merck Index: 13.8044.2001|
|Molecular Weight||M.W. 544.43|
|Solubility||Soluble in Water (50 mg/ml).|
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