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Puromycin | CAS [58-58-2] | Gene Selection Antibiotic| A.G.Scientific Puromycin is used for selecting mammalian cell lines, which have been transformed by vectors that express puromycin-N-acetyl-transferase (PAC). Catalog & bulk quantities by A.G.Scientif

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Puromycin dihydrochloride Solution

CAS: 58-58-2 Formula: C22H29N7O5.2HCl MW: 544.43 Appearance: Clear and colorless solution Purity: 100%
Hazardous

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P-1033-SOL 10 ml
$103.20
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5x2 ml
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Puromycin is an aminonucleoside antibiotic that causes early chain termination within the ribosome during translation. This inhibition of translation is effective in both in vivo and in vitro applications, making it an ideal tool for protein synthesis studies. While selection for E.Coli cells is possible with puromycin, it is more commonly and effectively used for mammalian cell selection.

It is active against gram-positive microorganisms, less active against acid-fast bacilli and more weakly active against gram-negative microorganisms. The growth of bacteria, protozoa, algae and mammalian cells is quickly halted by puromycin. However, cells with the pac gene have resistance. Its gene product is puromycin-N-acetyl-transferase which inactivates puromycin through acetylation.

Research has shown puromycin to be effective against certain tumors.

Puromycin is soluble in water and is often used as a selective agent in molecular biology research.

Puromycin’s longstanding application as a gene selection antibiotic, has a powerful new role in Genome editing utilizing the CRISPR/Cas9 system1,2.

1.) http://mbio.asm.org/content/6/4/e00861-15.full.pdf+html

2.) http://www.g3journal.org/content/early/2016/04/11/g3.116.028241.full.pdf+html

Additional Information

Synonyms Stylomycin, P638
Product # P-1033-SOL
CAS # 58-58-2
Chemical Name (S) 3'-[[2-Amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine,3'-(a-Amino-p-methoxy-hydocinnamamido)-3'-dexoy-N,N-dimethyladenosine.2HCl
Formula C22H29N7O5.2HCl
MW 544.43
Appearance Clear and colorless solution
Purity 100%
Solubility Soluble in DMSO (1M).
Storage Temp -20°C
Use Puromycin dihydrochloride is an aminonucleoside antibiotic, derived from the Streptomyces alboniger bacterium

Additional Information

Merck Index 13.8044.2001
MDL Number MFCD00012691
ChemACX X1017033-1
InChI InChI=1S/C22H29N7O5.2ClH/c1-28(2)19-17-20(25-10-24-19)29(11-26-17)22-18(31)16(15(9-30)34-22)27-21(32)14(23)8-12-4-6-13(33-3)7-5-12;;/h4-7,10-11,14-16,18,22,30-31H,8-9,23H2,1-3H3,(H,27,32);2*1H/t14-,15+,16+,18+,22+;;/m0../s1
SMILES CN(C)c1c2c(ncn1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)NC(=O)[C@H](Cc4ccc(cc4)OC)N)O.Cl.Cl

Additional Information

Handling Warning.Toxic. May be Carcinogenic. Wear gloves/mask when handling product. Avoid contact by all means of exposure. Protect from Moisture.

Additional Information

Certificate of Analysis 1 P-1033-SOL, F1128D.pdf
Certificate of Analysis 2 P-1033-SOL, F1128A.pdf
Certificate of Analysis 3 P-1033-SOL, F1081.pdf
E-Brochure Antibiotics Brochure

Additional Information

Puromycin dihydrochloride Solution

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