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Rocaglamide, 1 MG

Price$ 204.00
  • SKU: R-2420-1MG
  • Pack Size: 1 MG
Quantity
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NSC 326408; Roc-A; Rocaglamide A

84573-16-0

505.6

C29H31NO7

DMSO, Ethanol

-20°C


Rocaglamide is an immunosuppressant and a potent inhibitor of NF-B activation in T cells, with an almost complete inhibition at 200 nM. Suppresses cytokine production (IFN-, TNF, IL-2 and IL-4) and inhibits NF-AT in peripheral blood T cells at concentrations that do not impair NF-B and AP-1 activities. Also induces mitochondria-mediated apoptosis in leukemia cells and sensitizes CD95/CD95L-mediated apoptosis in malignant T-cells by differential regulation of CD95L and c-FLIP expression.

 

0.1 lbs



Research or further manufacturing use only, not for food or drug use.