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Product Description
17-AAG is an ansamycin antibiotic which acts as an anti-tumor agent. Specifically, 17-AAG binds and inhibits Hsp90 (Heat shock protein 90). Hsp90 is a protein chaperone that binds to signaling proteins, known as "client proteins." These client proteins include key cancer-relevant targets such as mutated p53, Bcr-Abl, Her2, Akt, Raf-1, B-Raf, and others. 17-AAG is able to disrupt the Hsp90-client protein complexes and lead to the degradation of the client proteins.
Additional Information
MSDS Documentation:COA Documentation: |
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| Product Number | A-1256 |
| CAS # | CAS [75747-14-7] |
| Chemical Name | 17-(Allylamino)-17-demethoxygeldanamycin, (17-AAG) |
| Chemical Formula | C31H43N3O8 |
| Appearance | Purple Powder |
| Melting Point | MP: 203-205°C |
| Molecular Weight | M.W. 585.7 |
| Purity | Purity: ≥98% |
| Solubility | DMSO, Methanol: Clear purple solution at 10mg/ml. |
| Storage Temp | -20°C |
Notice
All products sold by A.G. Scientific are strictly for Laboratory purposes only. They are not intended for Human Drug, Food Additive, Clinical or Household use.
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