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Product Description
A 83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50 values are 12, 45 and 7.5 nM respectively).
A 83-01 blocks phosphorylation of Smad2 and inhibits TGF-β -induced epithelial-to-mesenchymal transition. A 83-01 helps maintain homogeneity and long-term in vitro self-renewal of human induced pluripotent stem cells (iPSCs)
Additional Information
| Product Number | A-1764 |
| CAS # | 909910-43-6 |
| Chemical Name | 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide |
| Chemical Formula | C25H19N5S |
| Appearance | Pale Yellow Solid |
| Molecular Weight | 421.52 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (50 mM) |
| Storage Temp | Store at -20°C |
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